Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which been linked cellular uptake and efflux, apoptosis, vascular injury, oxidative endoplasmic reticulum stress, inflammation. Despite research efforts, pharmaceutical interventions, clinical trials spanning over several decades, consist...

normal 0 false false false en-us x-none ar-sa background: cisplatin (cis-diamminedichloroplatinum ii; cp) is used widely as an antitumor drug in clinics, but is accompanied with renal toxicity. cisplatin induced nephrotoxicity consists of change in kidney weight, histological changes in kidney and increase in serum creatinine (cr) and blood urea nitrogen (bun). this study was designed to find o...

background: in the past 20 years, a dramatic improvement in the prognosis of patients with hepatoblastoma (hb)has been achieved by combining surgery and chemotherapy in several national and international trials.materials and methods: four children ( 3 girl and 1 boy) aged 34 days, 4 months, 13 months, and 1 year with meanage of 6.53 (±5.15) months were presented to our center from 2002 to 2009 ...

Intensity of free radical oxidation processes in vivo (model induced oxidative stress) was studied after the probe introduction Vaccinium axillare Nakai fruit extract. Material and methods. Four groups (n = 40) white male CBA mice weighing 20–25 g were included experiment: 1 – intact control; 2–0.9 % sodium chloride solution administered per os for 10 days a dose ml/kg/day; 3 group “cisplatin” ...

AIMS To evaluate the adverse effect and survival outcome of weekly and triweekly cisplatin with radiotherapy in treatment of cervical cancer. METHODS After an extensive literature search between 1995-2011,we analyzed 7 studies to compare weekly cisplatin and triweekly cisplatin combined radiotherapy. RESULTS Our analysis established that weekly cisplatin has a lower risk of hematologic toxi...

Cisplatin is one of the most useful chemotherapeutics which performs its cytotoxic effectvia accumulation of platinum resulting in oxidative stress, and destruction of cell DNA. Thiscould probably cause secondary cancers in healthy tissues. Lipocalin2 (Lcn2) is a protein whichits expression is increased in oxidative stresses. Therefore, the present study was performedto evaluate the protective ...

Cisplatin resistance in head and neck squamous cell carcinoma (HNSCC) reduces survival. In this study we hypothesized that methylation of key genes mediates cisplatin resistance. We determined whether a demethylating drug, decitabine, could augment the anti-proliferative and apoptotic effects of cisplatin on SCC-25/CP, a cisplatin-resistant tongue SCC cell line. We showed that decitabine treatm...