conclusions oral mg supplementation did not protect the cp induced nephrotoxicity in diabetic rats. results cp administration in normoglycemic rats significantly elevated the serum levels of blood urea nitrogen (bun) and creatinine (cr) (p < 0.05). however, coadministration of cp and mg statistically increased the serum levels of bun and cr in both normoglycemic and diabetic animals when compar...

Despite reports of amifostine possibly protecting nephrotoxicity from cisplatin, it has not been recommended by any guidelines committees or routinely prescribed in clinical practice over the past decade. In this article, we review literature and regarding use oncology for protection against adverse effects certain chemotherapeutic agents, particular as a nephro-protectant patients receiving ci...

platinum is a metallic element, which may react with our cellular component through its involvement in cancer chemotherapy medications. cisplatin is one of the most useful antineoplastic drugs against human ovarian carcinoma, which has the central element of platinum in its structure. the nature of chemical interaction between platinum and cellular macromolecules is yet to be understood. we exa...

Cisplatin is widely used for the chemotherapy of head and neck cancer. However, it has a significant ototoxicity. Nigella sativa been scientifically proven to have numerous benefits included prevent adverse effect drug. This literature review aimed evaluate protective role N. oil against cisplatin-induced Relevant publications were searched from PubMed Google Scholar databases within last 10 ye...

OBJECTIVE This study aims to investigate the effect of intrapleural polymeric films containing cisplatin on the local recurrence of malignant pleural mesothelioma in a rat tumour model. METHODS An orthotopic rat recurrence model of malignant pleural mesothelioma was used. Five animals per group were evaluated. Polymeric films (4.5 cm diameter) for the local delivery of anticancer drug were co...

BACKGROUND Ovarian cancer is the leading cause of death among gynecological cancers. Cisplatin is one of the most effective anticancer drugs used in the treatment of ovarian cancer. Development of resistance to cisplatin limits its therapeutic use. Most of the anticancer drugs, including cisplatin, are believed to kill cancer cells by inducing apoptosis and a defect in apoptotic signaling can c...

A phase III trial conducted by Eastern Cooperative Oncology Group (ECOG) investigators assessed the possible impact of paclitaxel on survival, response, and toxicity in patients with advanced non-small-cell lung cancer. Three regimens were compared: cisplatin/etoposide, paclitaxel/ cisplatin/granulocyte colony-stimulating factor (G-CSF), and paclitaxel/ cisplatin. Patients were randomly assigne...

BACKGROUND Ovarian cancer is the most fatal of gynaecological malignancies, usually detected at a late stage with intraperitoneal dissemination. Appropriate preclinical models are needed that recapitulate both the histopathological and molecular features of human ovarian cancer for drug-efficacy analysis. METHODS Longitudinal studies comparing cisplatin performance either alone or in a novel ...

This paper presents a summary of the evidence review group (ERG) report into the clinical effectiveness and cost-effectiveness of topotecan in combination with cisplatin for the treatment of recurrent and stage IVB carcinoma of the cervix, in accordance with the licensed indication, based upon the evidence submission from the manufacturer to the National Institute for Health and Clinical Excell...

The protective effects of cochlear pre-conditioning have been documented, especially in regard to noise. Conditioning with moderate-intensity noise toughens the ear and makes it more resistant to damage from high-level noise exposures. The goal of the project was to determine whether cochlear pre-conditioning is effective in protecting against the ototoxic effects of cisplatin. Pre-conditioning...