Dictyostelium discoideum is a useful model for studying mechanisms of cisplatin drug sensitivity. Our previous findings, that mutations in sphingolipid metabolism genes confer cisplatin resistance in D. discoideum and in human cells, raised interest in the resistance mechanisms and their implications for cisplatin chemotherapy. Here we used expression microarrays to monitor physiological change...

One of the major complications in cancer chemotherapy with cisplatin as one of the important medicines in treatment regimens of different cancers is the development of resistance. One of the most described cellular defense mechanisms involved in resistance is glutathione (GSH), thus in this study, the effects of cisplatin on the total intracellular GSH level (GSHi) in some sensitive and resista...

Cisplatin is a conventional chemotherapeutic agent that binds covalently to purine DNA bases and mediates cellular apoptosis. A better understanding of the downstream cellular targets of cisplatin will provide information on its mechanism of action and help to understand the mechanism of drug resistance. In this study, we have investigated the effects of cisplatin in a panel of colon carcinoma ...

hydrogen sulfide (h2s) prevents and treats a variety of disorders via its cytoprotective effects. however, the effects of h2s on rats with cisplatin (cp) nephrotoxicity are unclear. the aim was to study the effects of h2s on rats with cp nephrotoxicity. thirty male sprague-dawley rats were divided into three groups: control group, nephrotoxic group received single dose of cp (6 mg kg-1) and nep...

background: according benefcial effects of  tribulus terrestris  (tt) extract on  tissue damage, the present study investigated the infuence of hydroalcoholic extract of tt plant on cisplatin (cis) (ebewe pharma, unterach, austria) induced renal tissue damage in male mice. methods: thirty mice were divided into five groups (n = 6). the first group (control) was treated with normal saline (0.9% ...

conclusions the pattern of pretreatment with o2 could change this potential and highly protective strategy against cp-induced nephropathy to an ineffective or even mildly deteriorating one. therefore, o2 administration before cp injection to patients with cancer, for therapeutic purposes or as a preconditioning approach, should be performed and investigated with caution until exact effects of d...

Introduction Liver inflammatory response occurring after toxic chemicals injection, such as cisplatin, causes the aggravation in liver damage. Lycopene, a carotenoid, has previously been proven to possess antioxidant, antiinflammatory and antiapoptotic properties. This study objective was evaluate for first time protective effects of lycopene cisplatin-induced damage based on disturbances serum...

Introduction: Cisplatin is a platinum-based drug widely used for the treatment of different cancers. Cell surface glycoconjugates play an important role in cell-cell interactions. The present investigation was carried out to study the toxic effects of double dose injection of cisplatin on cell surface glycoconjugates in rat as an experimental model. Methods: In this experimental study, 45 adul...

BACKGROUND Preoperative cisplatin alone may be as effective as cisplatin plus doxorubicin in standard-risk hepatoblastoma (a tumor involving three or fewer sectors of the liver that is associated with an alpha-fetoprotein level of >100 ng per milliliter). METHODS Children with standard-risk hepatoblastoma who were younger than 16 years of age were eligible for inclusion in the study. After th...

Magnetic nanoparticles have been highly regarded because of their unique properties, such as hyperthermia, medicine control release, and diagnostic applications. The main aim of the current paper is to offer a new system for the modification of Fe3O4 (SPIONs) superparamagnetic nanoparticles physically and chemically with polymers through physical retention. These modified nanoparticles have bee...