The prostaglandin (PG) EP(4) receptor subtype is expressed by peripheral sensory neurons. Although a potential role of EP(4) receptor in pain has been suggested, a limited number of selective ligands have made it difficult to explore the physiological functions of EP(4) or its potential as a new analgesic target. Here, we describe the in vitro and in vivo pharmacology of a novel EP(4) receptor ...

OBJECTIVE Representatives of five international critical care societies convened topic specialists and a nonexpert jury to review, assess, and report on studies of targeted temperature management and to provide clinical recommendations. DATA SOURCES Questions were allocated to experts who reviewed their areas, made formal presentations, and responded to questions. Jurors also performed indepe...

We investigate necessary and sufficient conditions for the existence of Bayesian-Nash equilibria that satisfy theCondorcet Jury Theorem (CJT ). In theBayesian game Gn among n jurors, we allow for arbitrary distribution on the types of jurors. In particular, any kind of dependency is possible. If each juror i has a “constant strategy”, σ i (that is, a strategy that is independent of the size n ≥...

The Sixth and Fourteenth Amendments to the U.S. Constitution guarantee criminal defendants the right to a jury trial and require that the elements of crimes be proved beyond a reasonable doubt. Academics, judges, and practitioners generally assume that these constitutional guarantees protect defendants. Recently, however, scholars and even members of the Supreme Court have suggested that expand...

We investigate the asymptotic properties of orthogonal polynomials for a class of inner products including the discrete Sobolev inner products 〈h, g〉 = ∫ hg dμ+ ∑m j=1 Nj i=0 Mj,ih (cj)g (cj), where μ is a certain type of complex measure on the real line, and cj are complex numbers in the complement of supp(μ). The Sobolev orthogonal polynomials are compared with the orthogonal polynomials corr...

Purpose To analyze the anti-inflammatory and antioxidative effects of Camellia japonica (CJ) on human corneal epithelial (HCE) cells and its therapeutic effects in a mouse model of experimental dry eye (EDE). Methods Camellia japonica extracts of varying concentrations (0.001%, 0.01%, and 0.1%) were used to treat HCE cells. Dichlorofluorescein diacetate (DCF-DA) and dihydroethidium (DHE) assa...

Recent research showed the involvement of prostaglandin E receptor subtype 4 (EP4) in hypersensitivity to inflammatory pain and suggested that the EP4 receptor is a potential target for the pharmacological treatment of inflammatory pain. We examined the effects of (S)-4-(1-(5-chloro-2-(4-fluorophenyoxy) benzamido)ethyl) benzoic acid (CJ-42794), a selective EP4 antagonist, on gastrointestinal ul...

M. Cui [email protected] Optics Research Group, Department of Applied Sciences, Technical University Delft, Lorentzweg 1, 2628 CJ Delft, The Netherlands R. N. Schouten Optics Research Group, Department of Applied Sciences, Technical University Delft, Lorentzweg 1, 2628 CJ Delft, The Netherlands N. Bhattacharya Optics Research Group, Department of Applied Sciences, Technical University Delft, Lor...