نتایج جستجو برای: clinical trial

تعداد نتایج: 1365604  

Journal: :Demography 2011
Nicholas H Wolfinger

Many studies have demonstrated that the children of divorce are disproportionately likely to end their own marriages. In previous work, I showed that the transmission of divorce between generations weakened substantially for General Social Survey (GSS) respondents interviewed between 1973 and 1996 (Wolfinger 1999); Li and Wu (2006, 2008) contended that my finding is a methodological artifact of...

Journal: :Biometrics 2016
María José García-Zattera Alejandro Jara Arnošt Komárek

Motivated by a longitudinal oral health study, we propose a flexible modeling approach for clustered time-to-event data, when the response of interest can only be determined to lie in an interval obtained from a sequence of examination times (interval-censored data) and on top of that, the determination of the occurrence of the event is subject to misclassification. The clustered time-to-event ...

Journal: :Lifetime data analysis 2006
Bin Zhang Yi Li Rebecca A Betensky

We investigate the effect of unobserved heterogeneity in the context of the linear transformation model for censored survival data in the clinical trials setting. The unobserved heterogeneity is represented by a frailty term, with unknown distribution, in the linear transformation model. The bias of the estimate under the assumption of no unobserved heterogeneity when it truly is present is obt...

Journal: :Lifetime data analysis 2010
M A Jonker D I Boomsma

Family survival data can be used to estimate the degree of genetic and environmental contributions to the age at onset of a disease or of a specific event in life. The data can be modeled with a correlated frailty model in which the frailty variable accounts for the degree of kinship within the family. The heritability (degree of heredity) of the age at a specific event in life (or the onset of...

Journal: :Statistics in medicine 2010
Xiaoyan Lin Lianming Wang

Interval-censored data occur naturally in many fields and the main feature is that the failure time of interest is not observed exactly, but is known to fall within some interval. In this paper, we propose a semiparametric probit model for analyzing case 2 interval-censored data as an alternative to the existing semiparametric models in the literature. Specifically, we propose to approximate th...

Journal: :Biometrika 2012
Kwun Chuen Gary Chan Ying Qing Chen Chong-Zhi Di

To study disease association with risk factors in epidemiologic studies, cross-sectional sampling is often more focused and less costly for recruiting study subjects who have already experienced initiating events. For time-to-event outcome, however, such a sampling strategy may be length biased. Coupled with censoring, analysis of length-biased data can be quite challenging, due to induced info...

2011
Charles Brocato

A typical indemnification clause requires the indemnitor to “indemnify and hold the indemnitee harmless.” It might also require the indemnitor to “defend” the indemnitee. While most legal authorities agree that the obligation to defend is different from the obligations to indemnify and hold harmless, many regard the promises to indemnify and hold harmless as synonymous, suggesting that either b...

Journal: :Journal of statistical theory and practice 2013
Shuai Chen Hongwei Zhao

Medical cost estimation is a challenging task when censoring of data is present. Although researchers have proposed methods for estimating mean costs, these are often derived from theory and are not always easy to understand. We provide an alternative method, based on a replace-from-the-right algorithm, for estimating mean costs more efficiently. We show that our estimator is equivalent to an e...

پایان نامه :دانشگاه آزاد اسلامی واحد علوم پزشکی تهران - دانشکده پزشکی 1389

هدف: این مطالعه مداخله ای به منظور بررسی اثر لیزرهای دیودی red با طول موج 635 نانومتر و infrared با طول موج 830 نانومتر بر حرکت اسپرم های زنده در انسان انجام شده است. روش مطالعه: این مطالعه به صورت یک بررسی مداخله ای (interventional) از نوع کارآزمایی بالینی تصادفی شاهددار (randomized controlled clinical trial) انجام شده است. از میان 55 نفر مرد مبتلا به ناباروری با ناباروری اولیه یا ثانویه مبتل...

پایان نامه :دانشگاه آزاد اسلامی واحد علوم پزشکی تهران - دانشکده پزشکی 1389

هدف: این مطالعه به منظور مقایسه اثر درمانی والپروات سدیم با نورتریپتیلین در بیماران مراجعه کننده به بیمارستان بوعلی با علائم سردرد کششی (tension) در سال 1388-1389 انجام شده است. روش مطالعه: این مطالعه به صورت یک بررسی مداخله ای (interventional) و در قالب یک کارآزمایی بالینی تصادفی (randomized clinical trial) انجام شده است. حجم نمونه مورد بررسی شامل 80 نفر از بیماران مبتلا به سردرد tension مراج...

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