Creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. Creatine supplements have shown beneficial effects on neurological disorders including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, Alzheimer's disease and stroke. However, the potential benefits of creatine for patients with convu...

Fifty children with drug resistant epilepsy were treated with the Medium Chain Triglyceride (MCT) Emulsion diet. Eight achieved complete control of seizures (four without anticonvulsant drugs), and with the addition of anticonvulsants four had seizures reduced in frequency by 90% and 10 by 50-90%. The best results were obtained with astatic myoclonic and absence seizures, but control of seizure...

Epilepsy is a neurological disease arising from abnormal and uncontrollable electrical firings of a group of neurons appearing in the central nervous system. Experimental epilepsy models have been developed to assess the pathophysiology of epileptic seizures and to search for new effective anti-epileptic drugs. This chapter is designed to describe characteristics of experimental epilepsy models...

PURPOSE In order to assess whether focal epileptic seizures can be detected and distinguished from exercise we evaluated four different heart rate variability (HRV) methods with short term moving window analysis of 30, 50 or 100 R-R intervals or seconds per analyzed window. METHODS The four methods consisted of: (1) reciprocal high frequency power based on Fast Fourier Transformation, (2) Car...

Within the group of anticonvulsant drugs Carbamazepine (CBZ) is typically used in treatment seizure disorders. It applied partial, tonic-clonic and mixed seizures due to epilepsy or other reasons, neuropathic pain, certain mental This paper gives a quick overview pharmacological properties CBZ including its metabolism pathway CYP interactions.

PURPOSE The diagnostic classification of disorders of consciousness is often challenging, particularly the distinction between epileptic and non-epileptic seizures. The aim of the study was to examine serum lactate as a diagnostic marker of transient loss of consciousness. METHOD Serum lactate levels in blood samples drawn within 2h of the event were compared retrospectively between patients ...

The onset of Dravet syndrome typically occurs within the first year, with prolonged, generalized, or unilateral clonic seizures triggered by fever. In the early stages, other types of refractory seizures usually present that include myoclonic seizures, atypical absences, and partial seizures. Electroencephalography (EEG) findings are not pathognomonic, and signs of cognitive arrest or deteriora...

We report a case of prolonged atrial fibrillation (AF) precipitated by new-onset generalized tonic-clonic convulsions and marijuana abuse in a developmentally normal 18-year-old adolescent with a structurally normal heart. Our case highlights an interesting association and a unique pathophysiology between generalized tonic-clonic convulsions, marijuana abuse, and AF. We suggest that seizures an...

A 47-year-old man presented with tonic-clonic seizures characterized by convulsions. He repeatedly exhibited despite treatment four anti-seizure medications. During the titration process of perampanel (PER), paradoxically increased in intensity and frequency, resulting trauma. Video electroencephalogram monitoring revealed interictal rapid rhythms generalized spikes documented atonic seizures. ...