Human UMP/CMP kinase (EC 2.7.4.14) is responsible for phosphorylation of CMP, UMP, and dCMP and also plays an important role in the activation of pyrimidine analogs, some of which are clinically useful anticancer or antiviral drugs. Previous kinetic data using recombinant or highly purified human UMP/CMP kinase showed that dCMP, as well as pyrimidine analog monophosphates, were much poorer subs...

INTRODUCTION Interactions of the ceria particles with polyurethane surfaces are of great interest for polishing processes used in modern semiconductor industry. Specifically, ceria abrasive nanoparticles and polyurethane polishing pads are now broadly used in the process called Chemical-Mechanical Planarization/Polishing (CMP) [1,2,3]. To optimize the process of CMP, various chemicals, abrasive...

Chemical mechanical polishing (CMP) has emerged as the planarization technique of choice in both front-end (STI) and back-end (ILD) integrated circuit manufacturing. Conventional CMP processes utilize a polyurethane polishing pad and liquid chemical slurry containing abrasive particles. More recent work has examined the use of a fixed abrasive CMP pad [1], in which abrasive material is embedded...

BACKGROUND Sperm coating protein beta-defensin 126 (DEFB126) is adsorbed onto the entire surface of macaque sperm in the caudal epididymis and is retained on viable sperm collected from the cervix and the uterine lumen of mated female macaques. We investigated the role of sperm coating protein DEFB126 in cervical mucus penetration (CMP). METHODS Cervical mucus (CM) was collected from peri-ovu...

BACKGROUND Theories, models, and frameworks used by implementation science, including Diffusion of Innovations, tend to focus on the adoption of one innovation, when often organizations may be facing multiple simultaneous adoption decisions. For instance, despite evidence that care management practices (CMPs) are helpful in managing chronic illness, there is still uneven adoption by physician o...

*Correspondence: [email protected] 1Department of Mathematics and Statistics, Georgetown University, 306 St. Mary’s Hall, Washington, DC, 20057, USA Full list of author information is available at the end of the article Abstract The Poisson, geometric and Bernoulli distributions are special cases of a flexible count distribution, namely the Conway-Maxwell-Poisson (CMP) distribution – a two-pa...

This paper considers the issue of document type diversity in the Comparative Manifestos Project (CMP). For many years the CMP has been collecting and coding a variety of documents, such as speeches, pamphlets, newspaper articles and leaflets, as manifesto proxies. By using previously unexplored archival material to perform controlled comparisons between different types of documents, this paper ...

PURPOSE Calprotectin is a cytosolic protein with immunomodulatory, antimicrobial, and antiproliferative actions. The concentration of calprotectin increases in infection, inflammation, and malignancy. We determined if calprotectin can be used as a marker for the diagnosis and follow-up of bowel inflammation in cow's milk protein allergy (CMPA). METHODS In total, 32 patients newly diagnosed wi...

not impose additional requirements beyond those imposed by state law. For that reason, this proposed action: • is not a ‘‘significant regulatory action’’ subject to review by the Office of Management and Budget under Executive Order 12866 (58 FR 51735, October 4, 1993); • does not impose an information collection burden under the provisions of the Paperwork Reduction Act (44 U.S.C. 3501 et seq....