OBJECTIVE to assess the knowledge of cytomegalovirus (CMV) infection among Dutch primary care midwives, and clinical approaches to informing women about CMV. DESIGN cross-sectional study, using self-administered questionnaires. PARTICIPANTS 330 Dutch primary care midwives. SETTING primary midwifery care practices across the Netherlands. MAIN OUTCOME Midwives' knowledge of CMV transmissi...

Human cytomegalovirus (CMV) is the most common cause of congenital infection, with morbidity and mortality at birth.1–5 Usually, there are no clinical symptoms for CMV during primary infection, reactivation, and re-infection with a different CMV strain, but infected individuals may transmit the virus via body fluids such as saliva, blood, cervical secretion, semen, 1–4 and urine. The risk of in...

OBJECTIVE To study the association between anti-ganglioside antibody responses and Guillan-Barré syndrome (GBS) after a recent cytomegalovirus (CMV) infection. METHODS Enzyme linked immunosorbant assay (ELISA) was undertaken on serum samples from 14 patients with GBS with recent cytomegalovirus (CMV) infection (CMV+GBS) and 12 without (CMV-GBS), 17 patients with other neurological diseases (O...

Cytomegalovirus (CMV) infections occur worldwide and primary infection usually occurs in early childhood and is often asymptomatic whereas primary infection in adults may result in symptomatic illness. CMV establishes a chronic latent infection with intermittent periods of reactivation. Primary infection or reactivation associate with increased mortality and morbidity in those who are immunocom...

BACKGROUND Cytomegalovirus (CMV) infection has been implicated as a cause of posttransplantation coronary artery disease in adults. The purpose of this retrospective observational study was to evaluate the effect of CMV on outcome after heart transplantation in children. METHODS AND RESULTS Risk factors tested were recipient age, sex, and pretransplantation CMV serology; use of anti-CMV proph...

OBJECTIVE Despite the use of immunosuppressive drugs, recurrent and de novo inflammatory bowel disease (IBD) can develop after orthotopic liver transplantation (OLT). Cytomegalovirus (CMV) infection has been suggested to play a role in the pathogenesis of IBD. The aim of this study was to investigate the role of CMV infection in the development of IBD after OLT. MATERIAL AND METHODS All 84 pa...

BACKGROUND Cytomegalovirus (CMV) infection and CMV disease are frequent complications in immunocompromised patients. In this study, the incidence of pulmonary CMV infection was analyzed in different groups of immunocompromised patients and the diagnostic value of immunostaining with anti-CMV antibodies in BAL cells was evaluated in regard to the diagnosis of CMV pneumonitis. METHODS Five hund...

Cytomegalovirus (CMV) infection is a major cause of morbidity in kidney transplant recipients. CMV seropositivity is common in the general population, with a reported prevalence ranging from 30 to 97% (Paya, 2001; Preiksaitis et al., 2005). After primary infection, CMV establishes life-long latency. During the past 2 decades, major advances in the management of CMV infection of transplant patie...

BACKGROUND Currently, there is no effective intervention for a primary cytomegalovirus (CMV) infection during pregnancy. METHODS We studied pregnant women with a primary CMV infection. The therapy group comprised women whose amniotic fluid contained either CMV or CMV DNA and who were offered intravenous CMV hyperimmune globulin at a dose of 200 U per kilogram of maternal weight. A prevention ...

In spite of improvements in diagnostics and prevention of CMV disease in recent decades, CMV infection still remains major concern in terms of diagnosis and therapy in recipients of allogeneic stem cells. Besides considerable morbidity with direct effects of CMV infection (hepatitis, gastrointestinal disease, pneumonia, retinitis), there are also indirect effects such as increased susceptibilit...