The paper elaborates methodological basis of collaborative networks (CN) complex adaptation. We consider challenges and underlying principles of the CN complex adaptation. Subsequently, the DIMA-methodology of the integrated CN modeling is considered. The paper ends with the presentation of the fivelevel CN complex adaptation concept and summarizing DIMA-methodology application in the CN comple...

Chrysanthemum plants are one of the most economically important in South Korea. Both virus and viroid can cause diseases economic damage to plants. In this study, we investigated detection seven viruses two viroids 350 chrysanthemum cultivated Yesan-gun, Chungcheongnam-do. Two viruses, B (CVB) tomato aspermy (TAV), viroids, chlorotic mottle (CChMVd) stunt (CSVd), were detected study. The six sa...

BACKGROUND In transplant patients, current cyclosporine (CsA) dose monitoring with classic pharmacokinetics has demonstrated limitations. Evaluation of the activity of calcineurin (CN), the serine-threonine phosphatase enzyme target of CsA, has been proposed as a reliable way to optimize CsA dosing. METHODS CN activity was measured in whole blood in an attempt to overcome the high variability...

N K and 3d atom L absorption spectra of hexacyano complexes in solid K Fe(CN) , Na Fe(CN) , K Cr(CN) , 2,3 4 6 4 6 3 6 K Mn(CN) , K Fe(CN) , and K Co(CN) have been measured by detecting the total electron yield. The N K spectra of the 3 6 3 6 3 6 complexes are very similar and differ only in intensity of the lowest-energy absorption band. The intensity of this feature 32 systematically decrease...

Treatment of Ni(NCS)2(PMe2Ph)2 with organic isocyanides CN-R gave five-coordinate isocyanide Ni(II) complexes, Ni(CN-R)(NCS)2(PMe2Ph)2 (R = C6H3-2,6-Me2 (1), t-Bu (2)). Interestingly, the corresponding reaction of Ni(NCS)2(P(n-Pr)3)2 with 2 equiv. of CN-t-Bu gave an unusual compound, which exists as an ion pair of the trigonal bipyramidal cation [Ni(P(n-Pr)3)2(CN-t-Bu)3]2+ (3) and the dinuclear...

Cain/cabin1 is an endogenous inhibitor of calcineurin (Cn), a calcium-dependent serine/threonine phosphatase involved in various cellular functions including apoptosis. We show here that during apoptosis cain/cabin1 is cleaved by calpain at the carboxyl terminus to generate a cleavage product with a molecular mass of 32 kDa as a necessary step leading to Cn-mediated cell death. Mouse cain/cabin...

BACKGROUND MET is a proto-oncogene with its copy number (CN) alterations been reported in some cancers, but not in primary intestinal diffuse large B-cell lymphoma (PI-DLBL) yet. METHODS In this retrospective study, we performed histology and chart reviews, immunohistochemistry and quantitative polymerase chain reaction for MET CN alterations on 28 surgically resected PI-DLBLs. RESULTS Ther...