According to classical dogma, the central nervous system (CNS) is defined as an immune privileged space. The basis of this theory was rooted in incomplete understanding CNS microenvironment, however, recent advances such identification resident dendritic cells (DC) brain and presence lymphatics have deepened our neuro-immune axis revolutionized field neuroimmunology. It now understood that many...

Anaplastic large cell lymphoma (ALCL) is a histological subtype of non-Hodgkin lymphoma, largely characterized by anaplastic kinase (ALK) positivity, resulting from the chromosomal translocation t(2;5). We report pediatric case ALK-positive ALCL with primary concomitant involvement bone and central nervous system (CNS); thereafter, literature review about CNS was conducted. According to analyze...