Introduction: Effects of exercise on different body systems, especially cardiovascular and musculoskeletal systems are evidenced. There is a dynamic homeostatic balance between coagulation and fibrinolysis in normal circulation. Effect of exercise and training on this homeostatic balance has been studied extensively but there are a few studies with regards to analysis of the effects of train...

Hemophilia B is a rare blood coagulation disorder. Complications such as bleeding and hematoma can cause necrosis of flaps, wound disruption, and the disturbance of wound healing. In particular, guidelines for flap operations in hemophilia B patients have still not been defined, and case reports are rare. We reconstructed the heel of a 41-year-old male hemophilia B patient using a reverse sural...

As fresh frozen plasma (FFP) loses coagulation factor activity during the production process, FFP therapy may not be feasible to completely replenish coagulation factor concentrations in a clinical setting. The aim of this study was to describe the results of early replacement coagulation factors with FFP in a simplified and idealized in vitro model of dilution. Six ml of whole blood drawn from...

The coagulation/fibrinolysis system is essential for wound healing after vascular injury. According to the standard paradigm, the synthesis of most coagulation factors is restricted to liver, platelets and endothelium. We challenged this interpretation by measuring coagulation factors in nine human primary cell types. FX mRNA was expressed by fibroblasts, visceral preadipocytes/adipocytes and h...

Preoperative examination for abdominal aortic aneurysms (AAAs) occasionally reveals an abnormal decrease in coagulation factors and thrombocytopenia, fulfilling the criteria for disseminated intravascular coagulation (DIC). Treatment of the underlying disorder is indispensable for alleviating DIC. We report an uncommon case of a patient with AAA and DIC who showed prolonged thrombocytopenia des...

The blood coagulation system of 66 consecutive patients undergoing consecutive liver transplantations was monitored by thrombelastograph and analytic coagulation profile. A poor preoperative coagulation state, decrease in levels of coagulation factors, progressive fibrinolysis, and whole blood clot lysis were observed during the preanhepatic and anhepatic stages of surgery. A further general de...

KB We usually use prestorage leukoreduced red blood cells to treat symptomatic anemia, and leukoreduced apheresis platelets or whole blood–derived platelets to treat thrombocytopenia. Plasma components are used less commonly, and their use generally is restricted to the treatment of bleeding associated with coagulation factor deficiencies—either isolated coagulation factors or multiple coagulat...

(A review of the blood coagulation system of fish). Hemostasis is a function of paramount importance when an animal is responding to an injury or has a blood coagulation disorder. It is important to stop the bleeding after a vascular injury, in order to prevent blood loss, so the body needs an effective coagulation mechanism. In fish, despite the fact that there are many studies about the intri...