OBJECTIVE In hyperlipidemia, dietary fish oil containing n-3 polyunsaturated fatty acids (PUFA) provokes plasma triacylglycerol lowering and hypocoagulant activity. Using APOE2 knock-in mice, the relation of these fish-oil effects with altered gene expression was investigated. METHODS AND RESULTS Male APOE2 knock-in mice, fed regular low-fat diet, had elevated plasma levels of triacylglycerol...

Approach: Literature review of the multifaceted interactions between platelets, coagulation and cancer. Results: Over the years, the links existing between cancer development, progression and occurrence of metastasis on one side and coagulation on the other have become obvious. Tumors seems to activate platelets whereas, platelets, on the other hand, through their capacity to activate and relea...

Bleeding is a common problem in major trauma. Coagulopathy could be detected in approximately 25% of all trauma patients on arrival in the emergency room. The reasons for that are blood loss, dilution of the remaining coagulation factors by fluids not containing coagulation factors, consumption of coagulation factors and hyperfibrinolysis. Hypothermia and acidosis are also well described contri...

Critically ill patients (CIP) are patients who, because of dysfunction or failure of one or more organs/systems depend on advanced instruments for monitoring and therapy for their survival. Coagulation abnormalities are common in CIP. The most common (35–44%) is thrombocytopenia (platelet count less than 150,000/ ll), due to sepsis, disseminated intravascular coagulation (DIC), thrombotic micro...

The effect of recombinant factor VIIa (rFVIIa) on blood loss was evaluated in cirrhotic patients undergoing orthotopic liver transplantation. In the present study, we explored the effect of rFVIIa on coagulation and fibrinolysis during orthotopic liver transplantation. Coagulation factors, parameters of thrombin generation and parameters of fibrinolysis were measured in six patients who had rec...

Disseminated intravascular coagulation (DIC) is a syndrome that may complicate a variety of diseases, including malignant disease. DIC is characterized by widespread, intravascular activation of coagulation (leading to intravascular fibrin deposition) and simultaneous consumption of coagulation factors and platelets (potentially resulting in bleeding). Clinically, DIC in cancer has, in general,...

BACKGROUND AND OBJECTIVES Altered levels of coagulation factors have been included among the abnormalities that may increase the risk of venous thromboembolism (VTE) in otherwise healthy subjects. INFORMATION SOURCES According to the studies that have been carried to test this hypothesis only elevated levels of factor VIII and fibrinogen emerged as independent risk factors for VTE. STATE OF...

The adsorption of coagulation factors was studied in the presence of the following decalcifying agents: Ion exchange resins, ammonium citrate, ammonium oxalate, a mixture of potassium and ammonium oxalate, and sodium E.D.T.A. Whichever decalcifying technique was used, the results were similar and only the results using human citrated plasma (1 part of citrate 0.38% to 9 parts of blood) are repo...