Vitamin B12 (cobalamin) is an essential coenzyme for nucleic acid synthesis. Animal protein is the major dietary source of vitamin B12. Deficiency of vitamin B12 leads to megaloblastic anemia, degeneration of the brain, spinal cord, peripheral nerves, and abnormalities of epithelial tissues. Two factors are necessary for the cure of megaloblastic anemia: one in food (extrinsic factor) and one i...

giardia lamblia is one of the most common intestinal protozoan parasites infecting human in the world. the goal of this study was searching for in-vitro effect of folic acid and cobalamin on adhesion and growth of g. lamblia as two important mechanisms in the pathogenesis in tyi-s-33 medium. g. lamblia trophozoites were obtained by in- vitro excystation procedure. three groups of giardia tropho...

vitamin b12 (cobalamin) is an essential coenzyme for nucleic acid synthesis. animal protein is the major dietary source of vitamin b12. deficiency of vitamin b12 leads to megaloblastic anemia, degeneration of the brain, spinal cord, peripheral nerves, and abnormalities of epithelial tissues. two factors are necessary for the cure of megaloblastic anemia: one in food (extrinsic factor) and one i...

background: vitamin b12 (cobalamin) deficiency can result in some clinical and paraclinical characteristics similar to what is seen in multiple sclerosis (ms) patients. this study aimed to evaluate the controversial association between vitamin b12 deficiency and ms. methods: we measured serum vitamin b12 in 60 patients with ms and 38 healthy controls. clinical disability was evaluated according...

Aim: Deficiency of cobalamin and folate during pregnancy is associated with megaloblastic anemia. Lower levels of folate and vitamin B12 were reported in mothers whose offspring had neural tube defects compared to unaffected controls. Increased methylmalonic acid (MMA) levels are a sensitive indicator of mild vitamin B12 deficiency and elevated homocysteine levels denote vitamin B12 or folate d...

Vitamin B12 deficiency causes a variety of symptoms in the hematologic, gastrointestinal tract, and neurologic deficit. We report rare case progressive gait disturbance, bradykinesia dysarthria which was that vitamin diagnosed as cause, improved after intramuscular cobalamin treatment. B12, homocysteine, methylmalonic acid tests are recommended for patients with even absence obvious anemia symp...

BACKGROUND Haptocorrin (HC) carries the major part of circulating cobalamin, but whether HC is altered on treatment with vitamin B12 remains unknown. METHODS Our study included 3 populations: a population of vegan men (n = 174; vegan population), of whom 63 were treated daily with 5 mg of oral vitamin B12 for 3 months; a group of patients with a previous methylmalonic acid (MMA) concentration...

Vitamin B12 (VB12) is an essential water-soluble vitamin that also known as Cobalamin [1]. It is composed of a corrin ring consisting of four pyrrole units and a cobalt ion at the center of the ring [2]. 1VB12 is manufactured by microorganisms present in the liver of animals bound to protein. The average B12 content of liver tissue is approximately 1.0 microgram/g of tissue in healthy adults [3...

True tinnitus is a phantom auditory perception arising from a source or trigger in the cochlea, brainstem, or at higher centers and has no detectable acoustic generator. The most accepted is the famous neurophysiologic model of Jastreboff, which stresses that tinnitus, is a subcortical perception and results from the processing of weak neural activity in the periphery. The aim of this study is ...

Vitamin B12, cobalamin, is a cobalt-containing ring-contracted modified tetrapyrrole that represents one of the most complex small molecules made by nature. In prokaryotes it utilised as cofactor, coenzyme, light sensor and gene regulator yet has restricted role in assisting only two enzymes within specific eukaryotes including mammals. This deployment disparity reflected another unique attribu...