Cholesterol has been implicated in the pathogenesis of Late-onset Alzheimer's disease (LOAD) and the Cholesteryl Ester Transfer Protein (CETP) is critical to cholesterol regulation within the cell, making CETP an Alzheimer’s disease candidate gene. Several studies have suggested that CETP I405V (rs5882) is associated with cognitive function and LOAD risk, but findings vary and most studies have...

Theory-based instructional design is a top priority in medical education. The goal of this Show and Tell article is to present our theory-driven approach to the design of instruction for clinical educators. We adopted cognitive load theory as a framework to design and evaluate a series of professional development workshops that were delivered at local, national and international academic confer...

Cognitive Load Theory (CLT) builds upon established models of human memory that include the subsystems of sensory, working and long-term memory. Working memory (WM) can only process a limited number of information elements at any given time. This constraint creates a "bottleneck" for learning. CLT identifies three types of cognitive load that impact WM: intrinsic load (associated with performin...

BACKGROUND Educators continue to search for better strategies for medical education. Although the unifying theme of reforms was "increasing interest in, attention to, and understanding of the knowledge base structures", it is difficult to achieve all these aspects via a single type of instruction. METHODS We used related key words to search in Google Scholar and Pubmed. Related search results...

Navigation structure and user familiarity are critical for user satisfaction, yet the mediating mechanisms by which they affect satisfaction remain unclear, especially from a cognitive perspective. To extend understanding of the drivers of user satisfaction with a website, this study focuses on the mediating roles of cognitive load and performance outcomes (in the form of efficiency and accurac...

In assistive technology design, it is indispensible to consider the sensory, physical and cognitive level of target users. Cognitive load is an important indicator of cognitive feedback during interaction and became the critical research issue in designing assistive user interfaces, incorporated with smartphone based assistive technology like in the android platform. In this paper, we proposed ...

The extent to which different locomotor tasks require cognitive control is not well characterized. In this article, the authors consider the potential increase in attentional demands associated with carrying an anterior load while clearing an obstacle. Nine healthy male volunteers participated in 80 walking trials, 20 in each of 4 conditions: 1 no load condition (NL) and 3 carrying conditions (...

Processing of semantic information in language comprehension has been suggested to be modulated by attentional resources. Consequently, cognitive load would be expected to reduce semantic priming, but studies have yielded inconsistent results. This study investigated whether cognitive load affects semantic activation in speech processing in older adults, and whether this is modulated by individ...

This paper describes an experiment that compared learners with contrasting learning styles, Active vs. Reflective, using three different strategies for learning programming via worked-examples: Pairedmethod, Structure-emphasising, and Completion. The quality of the learners’ acquired cognitive schemata was assessed in terms of their post-test performance. The experiment investigated variations ...

Information from load profile is useful for electricity suppliers to plan their generation, improving their market strategies and load balancing. Consumers in the new liberalized market have the opportunity of choosing their electricity suppliers between several suppliers and the possibility to access to new products and services from them. Hence they need the knowledge of load profile to help ...