the interaction between holo-transferin (htf) and colchicine (col) was investigated in the present of pb +2 ions under physiological conditions by using synchronous fluorescence spectra. the synchronous fluorescence spectra show a slight change of tryptophan residue micro-environment. synchronous fluorescence spectra show that the structure of the tyrosine residue environment was altered by int...

The xenobiotic-mediated induction of three major human liver cytochrome P450 genes, CYP2B6, CYP2C9, and CYP3A4, is known to be regulated by the constitutive androstane receptor (CAR) and the pregnane X receptor (PXR). CAR and PXR are regulated, at least in part, by the glucocorticoid receptor (GR) and the hypothesis of a signal transduction cascade GR-[CAR/PXR]-P450 has been proposed. This stud...

Recent studies have demonstrated that an inflammatory mechanism contributes to the pathogenesis of diabetic nephropathy (DN). It is also known that colchicine (Col) can prevent various renal injuries via its anti-inflammatory action. However, the effect of colchicine on DN has never been explored. This study was undertaken to elucidate the effect of colchicine on inflammation and extracellular ...

Cell stiffening induced by anticancer microtubule targeting drugs (MTDs) such as vinflunine (VFL), colchicine (COL), and docetaxel (DTX) can be driven crosstalk between actin filaments microtubules.

The ability of colchicine (Col) to interfere with suppressor cells specific for the soluble protein antigen human gamma globulin (HGG) has been examined. This interference may be the mechanism of the adjuvanticity promoted by Col. When injected into A/J mice at the appropriate time and concentration, both Col and cyclophosphamide promoted an adjuvant increase in the plaque-forming cell response...

PURPOSE To investigate beneficial effect of the readily available colchicine through its intravesical application on protamine/lipopolysaccharide induced interstitial cystitis model in rat and to compare its efficacy to the chondroitin sulphate available for clinical use. MATERIALS AND METHODS Twenty-four Wistar female rats were assigned to control (C), interstitial cystitis (IC), chondroitin...

BACKGROUND The Chuanhu anti-gout mixture has been used for many years in the treatment of gout in Chinese Traditional Medicine, and current methods for treatments for acute gouty arthritis have been either less effective or have had serious side effects. METHODS In this 12-week, double-blind, double-dummy, non-inferiority study, outpatient individuals with newly diagnosed acute gouty arthriti...

Lits, Kirschbaum, and Strong (2), using a transplantable lymphosarcoma in mice, found that colchicine would apparently cause complete re gression in some animals but that recurrence in evitably occurred. One of the most successful at tempts in treating a transplanted lymphosarcoma was reported by Heilman and Kendall (3). They showed that Compound E (ll-dehydro-17-hydroxycorticosterone) produced...

The main constituent of saffron, Crocus sativus L., is called Crocin (CR). Water-soluble carotenoids in CR possesses anti-inflammatory, analgesic, anti-edematous, as well anti-oxidant properties, to increase the number microtubules sheep brain and have neuroprotective effects. For example, Alzheimer's disease (AD), where harm hippocampal cortical neurons results memory cognitive impairment, amy...