background: the oncologic behavior of mucinous adenocarcinoma (ma) of colorectal differs from non-mucinous adenocarcinoma (nma). ma is more advanced at diagnosis and has a poorer prognosis than nma. we aimed to evaluate prognostic factors and survival rate in patients with ma compared with nma in western iran. methods: during 2008-2015 in a retrospective study, 83 patients with crc referred to ...

aim : leptin is a 16 kda polypeptide hormone which secreted by adipose tissue and has an important role in energy balance, insulin pathway and inflammation, because of that it may play an important role in colorectal cancer (crc). leptin exerts its effect through the leptin receptor (lepr) a member of the class i cytokine receptor family. background : we have investigated whether glutamine to a...

it is clear that colorectal cancer (crc) develops through multiple genetic and epigenetic pathways. these pathways may be determined on the basis of three molecular features: (i) mutations in dna mismatch repair genes, leading to a dna microsatellite instability (msi) phenotype, (ii) mutations in apc and other genes that activate wnt pathway, characterized by chromosomal instability (cin) pheno...

background : colorectal cancer, a major health concern worldwide, is the third most common form of cancer and second leading cause of cancer-related deaths. the flavonoids are naturally occurring diphenylpropanoids ubiquitous in plant foods and important components of the human diet. luteolin, a bioflavonoid, possesses many beneficial effects including antioxidant, anti-inflammatory, anti-aller...

Background: Cancer is the third leading cause of death in Iran. Cancer treatment is very costly and chemotherapy drugs are one of the main causes of the high cost of cancer treatment. The purpose of this study was to evaluate the cost of chemotherapy drugs of five most common cancers and identifying the factors might affect the costs of chemotherapy drugs in a one of the large provinces of Iran...

background and objectives: involvement of lymph nodes is an important prognostic factor in the most cancers, including colorectal cancer. in the recent years, invasion to blood and lymphatic vessels has been shown to predict involvement of lymph nodes and the number of involved nodes has been less studied issue. the aim of this study was determination of the relationship between the size of col...

Objective(s): Ten-eleven translocation (TET) family members have been shown to be involved in the development of many tumors. However, the biological role of the TET family and its mechanism of action in colorectal carcinogenesis and progression remain poorly understood. Materials and Methods:We measured the expression levels of TET family members in colorectal cancer (CRC) specimens, in the c...

in a cross-sectional study aiming to investigate the anatomical distribution of colorectal cancer in a six years period, patients file were studied and 150 patients with colorectal cancer were selected based on age, gender, place of residency, place of anatomical tumor and biological symptom. the findings indicated that 91(59.9) of patients had adenocarcinum, 54 (35.5) pulyp and 7 (4.6) had oth...

abstract: background: evidence suggests that the incidence of many cancers including bowel cancer vary according to socioeconomic status and education. in case of colorectal cancer, the direction of this association might be even different for anatomical subsites. the aim of this study was to describe the variation in the incidence of colorectal cancer by subsites across north of england and co...

abstract objective: colorectal cancer is a common (5000 new cases per year in iran) and lethal disease. regarding the high incidence (7 cases per 100000) and survival rate of colorectal cancer and the priority of prevalence index in cancer management, in this study, 1, 2-3 and 4-5 year point prevalence were determined according to survival data. method: in this study, survival and incidence dat...