INTRODUCTION Colorectal cancer (CRC) is the second leading cause of cancer-related deaths, but currently available noninvasive screening programs have achieved only a modest decrease in mortality. MicroRNAs (miRNA) play an important role in a wide array of biological processes and are commonly dysregulated in neoplasia. We aimed to evaluate the feasibility of fecal miRNAs as biomarkers for colo...

Discriminant markers are required for accurate cancer screening. We evaluated genes frequently methylated in colorectal neoplasia to identify the most discriminant ones. Four genes specifically methylated in colorectal cancer [bone morphogenetic protein 3 (BMP3), EYA2, aristaless-like homeobox-4 (ALX4), and vimentin] were selected from 41 candidate genes and evaluated on 74 cancers, 62 adenomas...

BACKGROUND MLH1 is one of six known genes responsible for DNA mismatch repair (MMR), whose inactivation leads to HNPCC. It is important to develop genotype-phenotype correlations for HNPCC, as is being done for other hereditary cancer syndromes, in order to guide surveillance and treatment strategies in the future. CASE PRESENTATION We report a 47 year-old male with hereditary nonpolyposis co...

In cancer cell lines and rodent models, calcium and vitamin D favorably modulate cell proliferation, differentiation, and apoptosis in colonic epithelia. These effects may be modulated by local expression of the calcium receptor (CaR), the vitamin D receptor (VDR), and the P450 cytochromes, CYP27B1 and CYP24A1; however, they have yet to be investigated in humans. To address this gap, we conduct...

BACKGROUND Few prospective studies have examined cancer incidence among vegetarians. OBJECTIVE We report cancer incidence among vegetarians and nonvegetarians in the European Prospective Investigation into Cancer and Nutrition-Oxford (EPIC-Oxford) study. DESIGN This was a prospective study of 63,550 men and women recruited throughout the United Kingdom in the 1990s. Cancer incidence was fol...

Aim : to analyze the safety and effectiveness of method cold snaring resection with preliminary hydropreparation when removing superficially colorectal epithelial neoplasms a diameter 5 25 mm. Material methods . The number complications disease recurrence after endoscopic excisions by “cold” mm was assessed. Results Neoplasms were removed in single block 89/122 (72.95 %) cases. 9 100 % cases, 1...

Aim : to analyze the safety and effectiveness of method cold snaring resection with preliminary hydropreparation when removing superficially colorectal epithelial neoplasms a diameter 5 25 mm. Material methods . The number complications disease recurrence after endoscopic excisions by “cold” mm was assessed. Results Neoplasms were removed in single block 89/122 (72.95 %) cases. 9 100 % cases, 1...

Cancer is a critical health threat in the world. It has an ongoing increasing trend.The aim of this study was to describe the trend, most common types of cancer and the gender ratio of cancer in Iran and its provinces. We searched PubMed, Google Scholar, Scopus, and Science directs from 2000 to 2017 using Keywords including “Cancer”, “Neoplasms”, “Malignancy”, “Tumor”, “Incidence”, “Epidemiolog...