An increased interest in gastro-entero-pancreatic neuroendocrine neoplasms (GEP NENs) has recently been observed. These are rare neoplasms and their detection in recent years has improved. Over 50% of GEP NENs are carcinoids, and they are usually found incidentally during surgery in the small intestine and appendix and at diagnosis in distant metastases, mainly to the liver. There is a need for...

BACKGROUND TNF-Related Apoptosis Inducing Ligand (TRAIL) is a promising agent for the induction of apoptosis in neoplastic tissues. Important determinants of TRAIL sensitivity are two intracellular proteins of the TRAIL pathway, caspase-8 and its anti-apoptotic competitor cellular Flice-Like Inhibitory Protein (cFLIP). METHODS The aim of this study was to investigate basic expression of caspa...

Introduction: Lung and colorectal carcinoma are commonly found in cancer often cause mortality worldwide. Colorectal (CRC) is the third most common of death. Although multiple primary cancers can exist, these two malignancies rarely happen simultaneously. This case report shows a patient diagnosed with squamous cell lung rectal adenocarcinoma metastases to liver, ocular, cerebrum. Case: A 54-ye...

Objective: To evaluate epidermal growth factor receptor and Ki-67 immunohistochemical expression in colorectal adenoma carcinoma cases, to relate their with the available clinicopathological data.Methods: The retrospective study was conducted at Faculty of Medicine, Kafrelsheikh University, Egypt, from September 2019 October 2020, comprised formalin-fixed paraffin-embedded specimens related cas...

Colorectal cancer (CRC) screening can reduce the incidence and mortality of CRC, many countries with moderate-to-high incidences CRC have implemented population programs. Colonoscopy plays a pivotal role in context as primary modality, diagnostic exam after positive noninvasive test, therapeutic procedure for resecting detected neoplasms, surveillance removal neoplastic lesions. Although colono...

BACKGROUND Investigations of genetic alterations and correlations with histology or morphology could provide further insights into colorectal carcinogenesis. Nevertheless, such genetic changes were less investigated in adenoma stage and a comprehensive survey of oncogenic mutations in EGFR signaling pathway according to different morphologic subtypes has not been performed. METHODS A total of...