Inflammation is involved in all stages of carcinogenesis. Inflammatory bowel disease, such as ulcerative colitis and Crohn's disease is a longstanding inflammatory disease of intestine with increased risk for colorectal cancer (CRC). Several molecular events involved in chronic inflammatory process are reported to contribute to multi-step carcinogenesis of CRC in the inflamed colon. They includ...

Malignant tumors of the small bowel are rare and little is known about their etiology, although adenocarcinomas share certain epidemiological features with colorectal cancer. This study investigated what cancers, if any, occurred as second neoplasms following adenocarcinomas, malignant carcinoid tumors, lymphomas, and sarcomas of the small bowel. For all 2581 cases of small bowel malignancy reg...

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62(1):10-29. 2. Sonnenberg A. Differences in the birth-cohort patterns of gastric cancer and peptic ulcer. Gut. 2010;59(6):736-743. 3. Susser M. Period effects, generation effects and age effects in peptic ulcer mortality. J Chronic Dis. 1982;35(1):29-40. 4. Zhao YS, Wang F, Chang D, Han B, You DY. Meta-analysis...

Lignans and proanthocyanidins are plant polyphenols that have shown protective properties against colorectal neoplasms in some human studies. Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to prospectively evaluate the association between lignan and proanthocyanidin intake, estimated from databases linked to a food frequency questionnaire, and adeno...

Colorectal endoscopic submucosal dissection (ESD) has become the standard of care for large superficial colorectal neoplasms, and allows en bloc resection of very large lesions [1]. The first goal of this technique is en bloc and R0 resection of large colorectal lesions to allow good pathological examination and determination of whether the endoscopic resection was curative. Such a conclusion i...

Introduction. At least 3% of all cancer cases are associated with hereditary changes in genes predisposing to malignant neoplasms. In addition the widely known BRCA1,2 genes, other involved equally DNA repair system and maintenance genome integrity, such as PALB2, CHEK2, being introduced into routine diagnosis. this review we present current information from recent studies on structure function...