Knowledge of the patterns of allelic loss has been useful in identifying the spectrum of the tumor suppressor genes involved in various tumor types. Such analyses in pancreatic carcinoma have been difficult due to the characteristic host desmoplastic reaction to the neoplasm. We have assembled the first allelotype of pancreatic adenocarcinoma, a survey for allelic loss among each chromosomal ar...

a Department of Gastroenterology, Royal Free Hospital, London , and b Department of Radiology, Royal Marsden Hospital, Sutton , UK; c Department of Pathology, Gothenburg University, Gothenburg , Sweden; d PET-Zentrum/ Klinik für Nuklearmedizin, Zentralklinik Bad Berka GmbH, Bad Berka , e Department of Radiology, Campus Virchow-Klinikum, and f Department of Internal Medicine, Charité-Universität...

Up-regulated cyclooxygenase (COX)-2 expression and prostaglandin E2 (PGE2)synthesis contribute causally to the early stages of colorectal neoplasia and carcinogenesis, yet COX-2 expression is barely detectable in normal and premalignant colorectal epithelium. Rather, COX-2 expression in nonmalignant colonic tissue is probably confined to subepithelial cells, such as fibroblasts. We established ...

The increasing prevalence of cancer worldwide has influenced the interest researchers to search for factors that may trigger oncogenesis in order prevent and treat cancer. There is a burning question, can allergic diseases cause or cancer? Numerous epidemiological studies have been conducted evaluated aspects relationship between occurrence cancers various localizations. results most these are ...

The epidemiology of genitourinary cancer varies depend on the organ. Prostate cancer is the most common solid neoplasm in males (15%) and renal cell neoplasm involves since 3% of all adult cancers. Urothelial carcinomas are the fourth most common tumors, after prostate, breast (females), lung and colorectal cancer. In particular, bladder cancer is the 9th most common cancer diagnosis worldwide....

Solitary metastatic pancreatic lesions comprise 0.5% to 3% of all pancreas neoplasms, most commonly arising from primary tumors of the kidney, lung, or colon. Synchronous metastatic pancreatic lesions are exceptionally rare. Only 25 cases of isolated colorectal pancreatic metastasis amenable to resection have been reported, 11 of those in the distal pancreas. To our knowledge we report the firs...

BACKGROUND Virtual colonoscopy is a potentially powerful tool for non-invasive colorectal evaluation. In vitro studies have established its accuracy in simulated polyp detection but little data exist regarding its use in clinical practice. AIMS To evaluate the ability of virtual colonoscopy to detect colorectal cancers and polyps in patients with endoscopically proven colorectal neoplasms and...

Non-polypoid (flat and depressed) colorectal neoplasms (NP-CRNs) are more difficult to detect by conventional white light colonoscopy (WLC) or computed tomography colonography, because the subtle findings can be difficult to distinguish from those of normal mucosa. Narrow band imaging (NBI) has been reported to highlight the mucosal capillaries of neoplastic lesions, and thus increase the detec...

Results: In the HIV-infected cohort, 72% (216/298) were screened for colorectal cancer. Colonoscopy was utilized in 45% (98/216) of patients and fecal occult blood test (FOBT) in 44% (95/298). There was no difference between the prevalence of polyps between the HIV-infected and uninfected groups (18% vs. 22%, p=0.42). There was a trend that HIV-infected patients were more likely to have advance...

Aberrant crypt foci (ACF) are microscopic lesions which have been postulated to precede the development of adenomatous polyps, the precursors to colorectal cancer. APC and ras gene mutations have been shown to be important early molecular events in the development of colorectal neoplasms. The objective of this study was to establish the nature and frequency of these two genetic alterations in A...