The Western dietary pattern is associated with higher risk of colorectal neoplasms. Evolutionary discordance could explain this association. We investigated associations of scores for 2 proposed diet patterns, the “Paleolithic” and the Mediterranean, with incident, sporadic colorectal adenomas in a case-control study of colorectal polyps conducted in Minnesota (1991–1994). Persons with no prior...

Obesity and central adiposity are associated with colorectal cancer risk and have been linked to inflammation. Inflammation is a complex, interactive response that may most accurately be summarized through multiple, simultaneously measured cytokines. In this cross-sectional analysis, we investigated associations of circulating plasma levels of C-reactive protein (CRP), tumor necrosis factor-α (...

When estimating survival from cancer registry data, there are several decisions to be made concerning record selection and method of calculation. For instance, should one use relative or disease-specific survival and how should one handle 'autopsy only' cases and cases with unknown cause of death. This study evaluates the effects of such decisions for survival from colorectal and prostate cance...

Serum C-reactive protein (CRP) is a sensitive marker of systemic inflammation. Because there is a well-recognized relationship between local inflammation and colorectal cancer, we aimed to evaluate whether serum CRP levels were associated with the occurrence of colorectal adenomas and serrated polyps using data from a large adenoma prevention trial. A total of 930 participants with a history of...

OBJECTIVE Inflammatory bowel disease (IBD) is commonly treated with thiopurines such as azathioprine and mercaptopurine for the maintenance of remission. Studies examining chemopreventive of these medications on colorectal neoplasm in IBD patients have yielded conflicting results. We performed a meta-analysis to assess the role of thiopurines for this indication. METHODS We performed a system...

The Western dietary pattern is associated with higher risk of colorectal neoplasms. Evolutionary discordance could explain this association. We investigated associations of scores for 2 proposed diet patterns, the "Paleolithic" and the Mediterranean, with incident, sporadic colorectal adenomas in a case-control study of colorectal polyps conducted in Minnesota (1991-1994). Persons with no prior...

Materials and methods 129 patients who underwent radical surgery for N0 colorectal cancer were selected and grouped into three age classes: <65 years, between 65 and 80, >80. A subpopulation of 44 patients with colorectal cancer in stage II was selected from the initial group for a comparison with a control population consisting of 63 patients who underwent radical surgery and adjuvant chemothe...

TGFbeta-related growth factors have been implicated in a variety of developmental and physiological processes in organisms ranging from nematodes to mammals. TGFbeta transduces its signal to the interior of the cell via Smad2, Smad3, and Smad4. We report the cloning and targeted disruption of the mouse Smad3 gene. Smad3 mutant mice are viable and fertile. Between 4 and 6 months of age, the Smad...

AIM: to estimate the implementation of original method that uses artificial intelligence (AI) detect colorectal neoplasms. MATERIALS AND METHODS: we selected 1070 colonoscopy videos from our archive with 5 types lesions: hyperplastic polyp, serrated adenoma, adenoma low-grade dysplasia, high-grade dysplasia and invasive cancer. Then 9838 informative frames were selected, including 6543 Lesions ...

Background & Aims: Many studies have demonstrated that Vitamin D has an important role in cell growth and proliferation and vitamin D receptor polymorphism has significant relationship with colorectal cancer (CRC). The aim of this study was to assess the incidence of VDR rs 2238136 polymorphism in Iranian population and to investigate the relationship between this single nucleotide polymorphism...