atorvastatin calcium, the lipid lowering agent, is taken as a model drug characterized by poor water solubility and bioavailability. in this study an attempt was made for preparation of nanocrystals using high pressure homogenization. a number of stabilizers were included as well as polymers at different concentrations, and the formulations were homogenized for ten cycles at a pressure of 1000 ...

Background and Objectives: In the original in vitro method for evaluation of iron bioavailability using caco-2 cell model, ferritin formation by cells is considered as a functional indicator of both absorption and utilization of iron. However, as iron is measured in the tested material and then ferritin concentration is measured in caco-2 cell lysate, it is almost impossible to have a concrete ...

Alpha-lipoic acid (ALA, thioctic acid), a naturally-occurring essential dithiol compound, has become common ingredient in many pharmaceutical and food supplement products (FSP), used oxidative stress-dependent pathologies; oral bioavailability of ALA is limited by pharmacokinetic particularities that reduce its therapeutic efficacy-reduced solubility, lack gastric stability hepatic degradation,...

present study determines not only the total amounts of metals (cr, cu and pb) in superficial agricultural soil of sistan area in eastern iran, but also the chemical partitioning of these elements in seven statistically selected cases. the analysis was run for local soil, soil treated by non-contaminated organic, compost and chemical fertilizers as well as soil treated by metal-contaminated fer...

the supersaturatable self-microemulsifying drug delivery system (s-smedds) represents a new thermodynamically stable formulation approach wherein it is designed to contain a reduced amount of surfactant and a water-soluble polymer (precipitation inhibitor or supersaturated promoter) to prevent precipitation of the drug by generating and maintaining a supersaturated state in-vivo. the supersatur...

background: the aim of this study was to determine bioavailability heavy metal concentrations of cu, cd, cr, co and zn and health risk assessment in different types of klang district, selangor (malaysia) urban surface soil using in physiologically based extraction test in vitro human digestion model. methods: a total of 76 urban surface soil was sampled based on seven different types of land us...

abstract the objective of present study was to evaluate pharmacokinetic parameters of dibudipine phytosolve after oral administration in rats. the solubility test was carried out to select suitable oily solvent for dibudipine. phytosolve formulation was prepared with a medium chain triglyceride (mct) oil (20%), soybean phospholipids (5%) and a 70% fructose solution (75%). the effect of polyol c...

BACKGROUND Once the patent of a brand-name drug expires, generic drugs are commercialized, and substitution from brand-name to generics may occur. Generic drug equivalence is evaluated through comparative bioavailability studies. Few studies have assessed outcomes after generic drug commercialization at a population level. We evaluated the impact of 3 generic angiotensin II receptor blockers co...