Aim To access the pharmacokinetics and comparative bioavailability of two tamoxifen citrate (TAM) formulations in 20 healthy Chinese male subjects under fasting conditions. Methods TAM test capsules and reference tablets were administered as a single dose on two treatment days separated by a 3-week washout period. After dosing, serial blood samples were collected for a period of 72 hr, and plas...

Carotenoids have been shown to have potential beneficial effects on human health which has led to an increasing interest in the study of their bioavailability. A Caco-2 cell model, as previously described, was employed to examine the percentage transfer of the carotenoids alpha-carotene, beta-carotene, lycopene, astaxanthin, beta-cryptoxanthin, lutein and zeaxanthin through an intact, highly di...

Resveratrol (RES) has been studied extensively as an anticancer agent. However, the anticancer effects of triacetylresveratrol (TRES, an acetylated analog of RES) which has higher bioavailability have not been well established. We comparatively evaluated their effects on cell proliferation, apoptosis and the molecular changes in STAT3, NFκB and apoptotic signaling pathways in pancreatic cancer ...

Introduction Toltrazuril (Tol) is used to prevent and combat coccidiosis. However, its low aqueous solubility and poor oral bioavailability limit clinical application. Methods To overcome the shortcomings, toltrazuril-hydroxypropyl-β-cyclodextrin inclusion complex (Tol-HP-β-CD) was prepared and characterized. The comparative plasma disposition kinetics of Tol was analyzed after a single orall...

Controlled release tablets containing 50 mg diclofenac sodium (DS) and 40% mastic with other natural additives were prepared. Drug release was examined and stability was studied using non-isothermal and isothermal thermogravimetric analysis (TGA). The bioavailability of two controlled release tablet formulations was studied and compared to that of commercial tablets, and rabbit stomachs were al...

the bioavailability of trace metals, their biological uptake and ecotoxiccological effect on soil biota can be better understood in terms of their chemical fractionation. the present study examined the mobility and availability of cd, cu, ni, pb and zn in sewage water – irrigated soils using sequential extraction technique as a basis for predicting metal uptake by plants. the residual fraction ...