نتایج جستجو برای: component reactions (mcrs)

تعداد نتایج: 772279  

Journal: :organic chemistry research 2015
mir rasul mousavi malek taher maghsoodlou fatemeh noori nourallah hazeri

a very efficient one-pot three-component synthesis of pyran derivatives has been improved by condensation of aldehydes and malononitrile with dimedone under 80 °c using sucrose as natural and biodegradable catalyst in water. this method offers some advantages including inexpensive, high to quantitative yields, short reaction time, and easy work-up. therefore, this methodology is entirely green ...

2017
Shunying Liu Wenfeng Yao Yuan Liu Qinghua Wei Jianghui Chen Xiang Wu Fei Xia Wenhao Hu

Multicomponent reactions (MCRs) represent an ideal organic synthesis tool for the rapid construction of complex molecules due to their step and atom economy. Compared to two-component reactions, the development of new MCRs has been greatly limited during the 170 years since the first MCR was reported. Theoretically, the trapping of an active intermediate generated from two components by a third...

A mild and efficient one-pot three-component and environmentally benign approach for the synthesis of a wide range of hydantoin annulated derivatives has been described. A multi-component reaction between a carbonyl compounds (ketone or aldehyde), potassium cyanide and ammonium carbonate (as cyanating agent and amine source, respectively leads to the formation of hydantoins. The proposed optimi...

Journal: :Molecules 2017
Heiner Eckert

Several novel methods, catalysts and reagents have been developed to improve organic synthesis. Synergistic effects between reactions, reagents and catalysts can lead to minor heats of reaction and occur as an inherent result of multicomponent reactions (MCRs) and their extensions. They enable syntheses to be performed at a low energy level and the number of synthesis steps to be drastically re...

Journal: :Current opinion in chemical biology 2010
James E Biggs-Houck Ashkaan Younai Jared T Shaw

Interest in multicomponent reactions (MCRs) has surged during the past two decades as interest in the efficient synthesis of small molecule libraries has gained prominence. MCRs fill an important niche in library synthesis by providing direct access to library compounds and by serving as starting points for Diversity-Oriented Synthesis (DOS). Recent advances in the area of MCR chemistry have in...

Journal: :iranian chemical communication 0
bozorg maddah imam hossein university, tehran, iran

a mild and efficient one-pot three-component and environmentally benign approach for the synthesis of a wide range of hydantoin annulated derivatives has been described. a multi-component reaction between a carbonyl compounds (ketone or aldehyde), potassium cyanide and ammonium carbonate (as cyanating agent and amine source, respectively leads to the formation of hydantoins. the proposed optimi...

Journal: :Organic & biomolecular chemistry 2015
Manuel G Ricardo Fidel E Morales Hilda Garay Osvaldo Reyes Dimitar Vasilev Ludger A Wessjohann Daniel G Rivera

Increasing the diversity of peptide cyclization methods is an effective way of accessing new types of macrocyclic chemotypes featuring a wide variety of ring sizes and topologies. Multicomponent reactions (MCRs) are processes capable of generating great levels of molecular diversity and complexity at low synthetic cost. In an attempt to further exploit MCRs in the field of cyclopeptides, we des...

2012
Bapurao B. Shingate

The rapid generation of diverse sets of complex molecules can be achieved by employing diversity oriented synthetic strategies in combination with so called complexity generating reactions. Multicomponent reactions (MCRs) have been emerged as an extremely powerful tool in combinatorial chemistry and drug discovery, since it offers significant advantages over conventional linear step syntheses, ...

2014
S. Moghimi

During the last few decades, Multi-Component Reactions (MCRs) have been studied as a facile route to assemble complex important structures in a small number of steps, while reducing production costs and environmental concerns. As a result, MCRs have attracted growing attention, leading to the development of new, highly selective methods for the synthesis of bioactive compounds such as natural p...

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