Open PHACTS is a pre-competitive project to answer scientific questions developed recently by the pharmaceutical industry. Having high quality biological interaction information in the Open PHACTS Discovery Platform is needed to answer multiple pathway related questions. To address this, updated WikiPathways data has been added to the platform. This data includes information about biological in...

viktor frankl, a neurologist and the founder of logo-therapy (1969) stated that “will to meaning” is the basic essence of the universe (1). logo-therapy means therapy through meaning, which is based on the premise that man has a will-to-meaning; the meaning thus lies in suffering(2). one of the most important human functions is discovering meaning in life, which is also considered as a sign of ...

Parkinson's disease (PD) is characterized by changes in movement, which are later followed by cognitive, behavioral and psychological changes. The objective of the present study was to correlate different tests used to examine executive functions in PD patients followed at a specialized outpatient clinic. Methods Thirty-five patients with idiopathic PD aged 63.0 years on average and with mean...

Numerous biographies and historical accounts describe Abraham Lincoln as a very somber, melancholy individual. Psychologists and historians postulate that Lincoln would have been diagnosed today with clinical depression. In the present study Lincoln’s history and symptoms are explained from the perspective of Adlerian therapy, which has been supported for the treatment of depression through pre...

INTRODUCTION Conceptual modeling appears to be the heart of good software development (Jackson, 2000). The creation of a conceptual model helps to understand the problem raised and represents the human-centered/ problem-oriented moment in the software process, as opposed to the computer-centered/software-oriented moment of the computational models (Blum, 1996). The main objective of human compu...