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Congenital heart defects (CHD) are the most common birth defects, occurring in about 0.7% of all newborn infants. There are multiple lines of evidence that genetic components are involved in developing CHD pathogenesis. An important aspect in understanding disease mechanisms is that in addition to contributions from a single disease-causing gene (usually seen in many familial cases of CHD), a m...

Arrhythmias figure prominently among the complications encountered in the varied and diverse population of patients with congenital heart disease, and are the leading cause of morbidity and mortality. The incidence generally increases as the patient ages, with multifactorial predisposing features that may include congenitally malformed or displaced conduction systems, altered hemodynamics, mech...

conclusions the right ventricular outflow tract palliation in children with cyanotic chd leads to long-term favorable outcome regarding improvement in oxygen saturation, increase in z score of both left and right pulmonary arteries and also considerable decrease in spell. also, death and complications are rare following rvot palliation. background the right ventricular outflow tract (rvot) pall...

AIM To assess whether four-dimensional (4D) spatiotemporal image correlation (STIC) can provide unique and novel information for diagnosing complex congenital heart diseases. METHODS A dynamic interactive 4D ultrasound system was used to examine 21 fetuses with complex congenital heart diseases and 25 fetuses with no apparent anomalies referred for prenatal diagnosis and management. Data acqu...

Cardiac catheterization was done for the first time 25 years ago by Forssman,’ who performed the maneuver on himself. However, this procedure was employed in the study and diagnosis of heart disease only after Cournand and Ranges2 demonstrated the value and safety of the method in 1941. The method was subsequently completed by the addition of several collateral techniques. The most useful appli...

https://e-kcj.org Chromosomal microarray (CMA) is a technology used to determine if there are microduplication or microdeletion pieces of genetic information. The prefix ‘Micro-’ indicates that less than 5 Mb sized genomic regions which has not been identified by conventional karyotyping using the G-band technique. These small gains and losses are called copy number variants (CNVs). A CNV is de...

Congenital heart disease is the leading cause of birth defect worldwide. Genetic mutation is a major contributor to certain types of congenital heart diseases, such as Tuberous sclerosis (TSC) and Marfan syndrome. Here I introduce a feasible pipeline for prenatal diagnosis of congenital heart diseases. Patients are enrolled due to either familial history of genetic mutation or abnormality durin...