نتایج جستجو برای: copper
تعداد نتایج: 82752 فیلتر نتایج به سال:
The deleterious effects of a disrupted copper metabolism are illustrated by hereditary diseases caused by mutations in the genes coding for the copper transporters ATP7A and ATP7B. Menkes disease, involving ATP7A, is a fatal neurodegenerative disorder of copper deficiency. Mutations in ATP7B lead to Wilson disease, which is characterized by a predominantly hepatic copper accumulation. The low i...
BACKGROUND Heart disease is the leading cause of death in diabetic patients, and defective copper metabolism may play important roles in the pathogenesis of diabetic cardiomyopathy (DCM). The present study sought to determine how myocardial copper status and key copper-proteins might become impaired by diabetes, and how they respond to treatment with the Cu (II)-selective chelator triethylenete...
Preparation of a glyoxylic acid copper complex and fabrication of fine copper wire by CO2 laser irradiation in air to a thin film of that complex have been investigated. Irradiating laser to the complex thin film spin-coated on a glass substrate, thin film of metallic copper was fabricated in areas that were subjected to laser irradiation in air. The thickness of this thin copper film was appro...
Copper tolerance in Chlorella vulgaris has been studied by comparing physiological properties and copper uptake in a wild type strain and a copper tolerant one. A concentration dependent reduction in growth rate, dry mass, and content of chlorophyll a, protein, sugars and amino acids was noticed in both strains at 1.0 and 400 !g l 1 copper. The reduction in all parameters was higher in the wild...
Dietary copper enters the body largely through the small intestine. Two membrane transporters are essential for this process. The high affinity copper uptake protein Ctr1 is responsible for making copper that enters via the apical membrane available in the cytosol for further utilization (1), whereas the copper-transporting ATPase ATP7A facilitates copper exit from the enterocytes into circulat...
As a trace element, copper has a crucial role in mammalian metabolism, but it can be toxic in excess. The importance of a balanced copper homeostasis is illustrated by several copper-associated disorders in man, such as Menkes and Wilson disease, and in a wide variety of animal models (eg, mice, dogs, and sheep). Proteins involved in controlling copper metabolism have been well studied in yeast...
X-linked inhibitor of apoptosis (XIAP), known primarily for its caspase inhibitory properties, has recently been shown to interact with and regulate the levels of COMMD1, a protein associated with a form of canine copper toxicosis. Here, we describe a role for XIAP in copper metabolism. We find that XIAP levels are greatly reduced by intracellular copper accumulation in Wilson's disease and oth...
The sorption of copper ions onto natural bamboo sawdust with cellulose-lignin polymeric structure strongly depends on pH. The adsorption capacity for copper ions increases as increasing pH and copper loadings. The fitting of copper pH boundary curve by NEM surface complexation models shows that: three-sites model including the ion exchange reaction of permanent charge fits better than two-sites...
Copper is a trace element present in all tissues and is required for cellular respiration, peptide amidation, neurotransmitter biosynthesis, pigment formation, and connective tissue strength. Copper is a cofactor for numerous enzymes and plays an important role in central nervous system development; low concentrations of copper may result in incomplete development, whereas excess copper maybe i...
Copper mining is one of the largest economic activities in Zambia, comprising close to ten percent of GDP. Between 2003 and 2008, the price of copper increased by over 400 percent. In response, copper production in Zambia increased by 70 percent and employment in copper mining increased by nearly 200 percent. This paper examines the effect of this economic shock on sexual behavior and the sprea...
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