Introduction: The aim of study was to compare umbilical cord blood selenium levels in respiratory distress syndrome (RDS) and non RDS preterm babies.    Methods: Umbilical cord blood selenium levels of all preterm newborn born during a 6-month period were enrolled in the study. They were divided into two groups: RDS and non RDS. Selenium level was assessed by using electro-thermal atomic ab...

background hypovitaminosis d has been associated with the development of gestational diabetes mellitus (gdm) in many observational studies. objectives we report the first study of the impact of prenatal vitamin d supplementation on postpartum dysglycemia in gdm patients in a randomized clinical trial. patients and methods women with gdm at 12 - 32 weeks of gestation were assigned randomly to ei...

the cytotoxic activity of natural killer cells is usually tested by radioactive assay csi cr release assay), which detects the release of cytoplasmic contents after plasma membrane disintegration of dying cells. in contrast to this indirect evaluation of cytotoxicity, the assessment of cell damage by flow cytometry aims to provide a more exact characterization of the death pathway via detection...

objectives: the study of erythropoiesis needs to develop the methods for erythroid progenitor cells (epcs) culture using stem cell potency to differentiate into variety of hematopoietic cells lineages. in this study, we induced differentiation of cord blood stem cells into erythroid progenitor cells in a semisolid culture media. materials and methods: cord blood mononuclear cells were isolate...

conclusions our results suggested that cb-nk cells progenitors could proliferate and differentiate on feeder layer of amnion membrane mscs in combination with specific cytokines to produce nk cells for immunotherapy. results combination of cytokines and msc layer yielded significant fold expansion in comparison with cytokines without feeder conditions (day 7: 5.2 ± 1.12 and 2 ± 0.78, respective...

introduction: the fetus needs a considerable amount of cholesterol for the development of tissues and organs.  studies have suggested that genetic and environmental factors influence the composition of cord blood lipoproteins.  in this study, we aim to assess the effect of gestational age, sex and birth weight on the cord blood lipoproteins. methods: we collected umbilical cord blood samples fr...

background: induced pluripotent stem cells (ipscs) can be obtained from autologous cells for therapeutic purposes. so, far, many studies have been done to produce induced pluripotent cells by transferring specific pluripotency genes using different methods. in this study, pluripotency gene expression induced by external stresses was assessed in cord blood mononuclear cells. methods: in this exp...

Background: The main objective of this study was to systematically review the reported potency of cord blood stem cells in treating patients with neurological disorders such as cerebral palsy.  Methods: PubMed, Scopus, and Cochrane were searched thoroughly on September 2016 using the following search terms: “Umbilical cord blood stem cells” AND “development” AND “cerebral palsy” to find articl...

Background: Umbilical cord blood (UCB) is an alternative source of hematopoietic stem cell transplantation (HSCT), used in Leukemia treatment. CD26+ cells, a fraction of CD34 positive cells, are a major population of UCB cells which negatively regulate the in vivo homing and engraftment of HSCs. CD26 is highly expressed in various cells such as HSCs, immune cells, fibroblasts, and epithelial ce...