We sought to test whether the peak systolic velocity of mitral annular longitudinal movement (S') measured by pulsed tissue Doppler imaging technique is useful to assess global left ventricular (LV) contractility under various LV inotropic conditions, including regional wall motion abnormality. In addition, the accuracy of S' relative to LV ejection fraction (EF), a conventional index of LV con...

On the supposition that pericoronary lymphatics play an important role in the efflux of interstitial fluid from the blood vessel wall, we examined the morphology of pericoronary arterial lymphatics in the dog. After ligation of the principal epicardial drainage lymphatics, after ligation of the left anterior descending coronary artery, after induced pericoronary inflammation and after instillat...

T coronary-sinus reduction described by Verheye et al. in this issue of the Journal (pages 519–527) revives an old therapeutic concept. Between 1948 and 1968, Cleveland surgeon Claude Beck performed coronary-sinus ligation in more than 1000 patients, aiming to improve myocardial oxygenation. Despite Beck’s reports of impressive efficacy, few surgeons adopted his techniques. The history of this ...

Coexistence of chronic kidney disease (CKD) and heart failure (HF) in humans is associated with poor outcome. We hypothesized that preexistent CKD worsens cardiac outcome after myocardial infarction, and conversely that ensuing HF worsens progression of CKD. Subtotally nephrectomized (SNX) or sham-operated (CON) rats were subjected to coronary ligation (CL) or sham surgery in week 9 to realize ...

The effect of acute alterations in coronary blood flow (CBF) on left ventricular (LV) end-diastolic wall thickness was measured by reflected ultrasound in twelve anesthetized dogs. During five minutes of coronary ligation, wall thickness decreased from a control of 9.0 ± 0.3 mm to 8.1 ± 0.3 mm (P < 0.001); during reperfusion (reactive hyperemia), wall thickness was greater than control (10.2 ± ...

BACKGROUND To test the hypothesis that the heat shock response is associated with myocardial salvage, the heat stress protein (HSP) content of cardiac tissue was increased by either ischemic or thermal stress. METHODS AND RESULTS Rabbits were divided into four groups. Ischemic pretreatment (n = 15) comprised four 5-minute episodes of coronary ligation separated by 10 minutes of reperfusion. T...

Aneurysmal coronary artery disease (ACAD) comprises both coronary artery aneurysms (CAA) and coronary artery ectasia (CAE). The reported prevalence of ACAD varies widely from 0.2 to 10%, with male predominance and a predilection for the right coronary artery (RCA). Atherosclerosis is the commonest cause of ACAD in adults, while Kawasaki disease is the commonest cause in children and adolescents...

The cause of chest pain in angina pectoris and myocardial infarction is not yet clear at present. As one of its mechanisms Lewis, Katz, Raab and other authors ascribed it to the pain producing substances originated from the ischemic region of the myocardium. More recently bradykinin, which is known to have strong pain producing and hypotensive actions, was suggested by Burch and DePasqualel as ...

conclusions the ligation method with attention to the modifications described further in the article is a simple, safe and cost effective option for the management of urethral prolapse.rnmaintaining the inflated balloon of the foley catheter with timed catheter removal especially adds predictability to this technique. results the mean age of the patients was 6 years old (ranging from 3 to 8 yea...