Several corticosteroids, such as prednisolone, dexamethasone and hydrocortisone/cortisol, are prescribed to suppress inflammation in a range of conditions. This article aims to update knowledge and encourage a review of practice. The emphasis will be on monitoring the adverse effects of medication and on patient education. After reading this article you should be able to: Explain the rationale ...

The purpose of this paper is to report on the possible deleterious effect of corticosteroids in central serous chorioretinopathy (CSCR). We will describe three patients in whom CSCR was induced or aggravated by corticosteroids. Despite multiple reports describing the onset of CSCR or aggravation of existing lesions with corticosteroids, they are still used by some ophthalmologists for the treat...

Purpose Corticosteroids remain the mainstay of treatment for inflammatory diseases almost 80 years after their first clinical use. Topical ophthalmic formulations of corticosteroids have been available to treat disease of the anterior segment of the eye, but the approval of corticosteroids to treat vitreoretinal diseases, including vein occlusion, diabetic macular edema, and uveitis, has occurr...

cultured with cytomix (p<0.05, all comparisons) and each was decreased by dexamethasone 10-6 M (p<0.05, all comparisons). To determine if these in vitro observations are reflected in vivo, exhaled NO was measured in 64 normal subjects, 22 asthmatics not taking corticosteroids, and 36 asthmatics taking inhaled corticosteroids. Peak exhaled NO levels were increased in asthmatics not taking cortic...

Although corticosteroids are an effective treatment for induction of remission in inflammatory bowel disease (IBD), many patients are dependent on or refractory to corticosteroids. This review is based on scrutinizing current literature with emphasis on randomized controlled trials, meta-analyses, and Cochrane reviews on the management of IBD refractory to corticosteroids. Based on this evidenc...

BACKGROUND The benefit of corticosteroids in community-acquired pneumonia (CAP) remains controversial. We did a meta-analysis to include all the randomized controlled trials (RCTs) which used corticosteroids as adjunctive therapy, to examine the benefits and risks of corticosteroids in the treatment of CAP in adults. METHODS Databases including Pubmed, EMBASE, the Cochrane controlled trials r...

BACKGROUND Corticosteroids are commonly used in the management of primary central nervous system (CNS) tumors and CNS metastases to treat cancer- and treatment-related cerebral edema and improve neurologic function. However, they are also associated with significant morbidity and mortality, given their wide range of adverse effects. PURPOSE OF REVIEW To review the mechanism of action, pharmac...

Cushing syndrome (CS) is an endocrinological disorder characterized by increased blood cortisol level. It either due to excessive endogenous release of steroids (e.g., pituitary adenoma or adrenal hyperplasia) exogenous administration steroids. Iatrogenic the most common form syndrome. The vast majority cases are oral parenteral steroid preparations, which commonly prescribed for pulmonary, ren...

The efficacy of topical corticosteroids as ocular anti-inflammatory agents following cataract surgery is well-documented. They also help to prevent a number of complications associated with post-operative ocular inflammation, including corneal edema and cystoid macular edema. However, topical corticosteroids are associated with side effects, such as increased intraocular pressure (IOP). Indeed,...

Aim: Little is known regarding the relationship between use of oral corticosteroids and hip fracture in the elderly in Taiwan. The aim of the study was to examine this issue. Methods: A retrospective population-based case-control study using the database of the Taiwan National Health Insurance Program (2000-2013) was conducted. We identified 4538 individuals aged ≥ 65 years with newly diagnosed...