Cigarette smokers with asthma are insensitive to the therapeutic effects of corticosteroids. It is not known whether this insensitivity to corticosteroids in smokers affects tissue sites beyond the airways. A total of 75 asthmatic subjects (39 smokers) and 78 healthy controls (30 smokers) were recruited to an observational study. The cutaneous and peripheral blood lymphocyte responses to cortic...

BACKGROUND Clear strategies to optimise the use of corticosteroids in ulcerative colitis are lacking. AIM A meta-analysis was undertaken to examine critically the role of rectal corticosteroids in the management of active distal ulcerative colitis. METHODS All reported randomised controlled trials were retrieved by searching the Medline and EMBASE databases and the bibliographies of relevan...

Corticosteroids, such as prednisone and dexamethasone, are commonly prescribed medications that suppress the immune system and decrease inflammation. Common side effects of long-term treatment with corticosteroids include weight gain, osteoporosis, and diabetes mellitus. This paper reviews the literature on psychiatric and cognitive changes during corticosteroid therapy and potential treatment ...

BACKGROUND The potential benefits of corticosteroids for septic shock may depend on initial mortality risk. OBJECTIVE We determined associations between corticosteroids and outcomes in children with septic shock who were stratified by initial mortality risk. METHODS We conducted a retrospective analysis of an ongoing, multi-center pediatric septic shock clinical and biological database. Usi...