Exposure to prenatal stress (PNS) can lead long-lasting neurobiological and behavioral consequences for the offspring, which may enhance susceptibility mental disorders. The hypothalamus-pituitary-adrenal (HPA) axis immune system are two major factors involved in response. Here, we performed a systematic review meta-analysis of rodent studies that investigated effects PNS exposure on HPA inflam...

Objectives. Hypothalamic-Pituitary-Adrenal axis function may be abnormal in rheumatoid arthritis (RA). A pilot study in 7 patients suggested impaired glucocorticoid feedback in some patients after the dexamethasone-corticotrophin releasing hormone (CRH) test. This study aimed to investigate the dexamethasone-corticotrophin releasing factor test in a larger group of patients and relate the resul...

this study explored the effects of gnrh agonist (gnrha) immunity on expression of fshr mrna in pituitary and fshr protein in uteri, and also confirmed its efficacy on uterine development. 42 prepuberty and non cyclic ewes were assigned to 6 experimental groups (eg) during anestrus season. animals in eg-i, eg-ii and eg-iii were subcutaneously injected with 200, 300 and 400 μg alarelin antigens (...

Corticotrophin-releasing hormone (CRH) is a 41 amino-acid peptide which was isolated and characterised exactly two decades ago (1). It is distributed heterogeneously throughout the central nervous system (CNS) (2) and, due both to its ability to stimulate the release of adrenocorticotrophic hormone (ACTH) from the pituitary and to its numerous extra-hypophyseal biological effects, is now consid...