An efficient strategy for mapping human genes that cause recessive traits has been devised that uses mapped restriction fragment length polymorphisms (RFLPs) and the DNA of affected children from consanguineous marriages. The method involves detection of the disease locus by virtue of the fact that the adjacent region will preferentially be homozygous by descent in such inbred children. A singl...

First cousins, a male and a female, with a new type of hidrotic ectodermal dysplasia are described. They were each the result of first cousin marriage from the Egyptian Karaite community. They both had partial adontia, conical peg-shaped teeth, fine hair that did not grow long, normal sweating, eversion of lips, and pronounced facial similarity. The male had cleft lip on the right side while th...

Psychological traits exhibit substantial variation worldwide, especially among the so-called WEIRD populations. Such psychological could be explained by intensity of kinship family ties that, we hypothesize, depends on reception innovations in organizations. These originated from several centers that also spread other crucial novelties such as agriculture. Less exposed to these organizations, a...

In a population practicing consanguineous marriage, rare recessive lethal alleles (RRLA) have higher chances of affecting phenotypes. As inbreeding causes more homozygosity and subsequently more deaths, the loss of individuals with RRLA decreases the frequency of these alleles. Although this phenomenon is well studied in general, here some hitherto unstudied cases are presented. An analytical f...

The present study was conducted to determine the prevalence of myopia in young students of Bahaudin Zakariya University, Multan. A total sample of 620 students of both gender (male=295; female=325) was collected during 2014. The data was divided in two breeding pattern groups, five groups on account of age at myopia onset and different family size. Out of 620 subjects, 150 had myopia (male=85; ...

Marriages among the Sikh minority of the Districts of Swat, Bunair and Shangla (NWFP, Pakistan) were studied where the frequency of consanguineous marriages was found to be 21%. Marriages with distant relatives were 29.4% in the population. The inbreeding coefficient for the population was calculated to be 0.0127. Only three types of first cousin marriages (MSD, MBD and FSD) were recorded. Marr...

Consanguinity or inter-cousin marriage is a phenomenon quite prevalent in certain regions around the globe. Consanguineous parents have a higher risk of having offspring with congenital disorders. It is difficult to model large scale consanguineous parental populations because of disparate cultural issues unique to regions and cultures across the globe. Although consanguinity has previously bee...

Consanguinity ("blood relation", from the Latin consanguinitas ) is the property of being from the same kinship as another person. In that aspect, consanguinity is the quality of being descended from the same ancestor as another person. Consanguineous marriage is frequent in many populations. In fact, it has been recently estimated that consanguineous couples and their progeny suppose about 10....

The effects of religion, population sub-division and geography on the prevalence of deaf-mutism were investigated using information collected in the 1921 Census of Punjab. The total sample size was 9.36 million, and comprised data on thirteen Hindu castes, seventeen Muslim biraderis and two Sikh castes. A two-way analysis of variance comparing males in Hindu castes in which consanguineous marri...