Coordination polymer particles have attracted a great deal of attention due to their characteristic properties and diverse applications in the fields of gas storage, catalysis, optics, sensing, electronics, photochemistry, and biology. Herein, we investigated shape transformation reactions of zinc 5, 10, 15, 20-tetra(4-pyridyl)-21 H, 23 H-porphine (ZnTPyP)-containing coordination polymer partic...

There is a pressing need for more effective and selective therapies for cancer and other diseases. Consequently, much effort is being devoted to the development of alternative experimental approaches based on selective systems, which are designed to be specifically directed against target cells. In addition, a large number of highly potent therapeutic molecules are being discovered. However, th...

Potential antimicrobial agents may be effective if they are delivered efficiently to their site of action. In many cases, lack of permeability through the cell membrane is the main problem. One of the possible solutions could be a novel intracellular delivery system involving cell-penetrating peptides (CPPs), which may improve the efficiency of many new biopharmaceuticals. Among other things, C...

In the era of Big Data and Internet-of-Things (IoT), all real-world environments are gradually becoming cyber-physical (e.g., emergency management, healthcare, smart manufacturing, etc.), with the presence of connected devices and embedded ICT systems (e.g., smartphones, sensors, actuators) producing huge amounts of data and events that influence the enactment of the Cyber Physical Processes (C...

Chronic Pelvic Pain (CPP) and Chronic Pelvic Pain Syndrome (CPPS) have a significant impact on men and women of reproductive and nonreproductive age, with a considerable burden on overall quality of life (QoL) and on psychological, functional, and behavioural status. Moreover, diagnostic and therapeutic difficulties are remarkable features in many patients. Therefore evaluation, assessment and ...

Prostatitis is a condition in which the prostate gland becomes inflamed, either as a result of a bacterial infection, decreased immune function, or a reduction in muscle-related function that affects 9% of males. Prostatitis represents a mix of conditions, including acute prostatitis, chronic bacterial prostatitis, and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), which accounts f...

Cell-penetrating peptides are short, often hydrophilic peptides that get access to the intracellular milieu. They have aroused great interest both in academic and applied research. First, cellular internalization of CPPs often involves the crossing of a biological membrane (plasma or vesicular), thus challenging the view of the non-permeability of these structures to large hydrophilic molecules...

Experience-dependent synaptic plasticity refines brain circuits during development. To identify novel protein synthesis-dependent mechanisms contributing to experience-dependent plasticity, we conducted a quantitative proteomic screen of the nascent proteome in response to visual experience in Xenopus optic tectum using bio-orthogonal metabolic labeling (BONCAT). We identified 83 differentially...

Introduction Chronic pelvic pain syndrome (CPPS) is a frequent urological diagnosis that affects men’s quality of life. Extracorporeal shockwave therapy (ESWT) recent treatment option for patients with CPPS. We evaluated ESWT’s short and long – term efficacy in managing CPPS.Methods This prospective self-controlled study included 75 diagnosed CPPS at our tertiary clinic between January 2017-Jun...

118 IDENTIFYING CHRONIC PROSTATITIS/ CHRONIC PELVIC PAIN SYNDROME FOR EPIDEMIOLOGIC STUDIES J. Quentin Clemens, Lara Hilton, Marika Suttorp, Sandra Berry. The purpose of this study was to assess the sensitivity and specificity of the definition in the NIHChronic Prostatitis Symptom Index (NIHCPSI) used by J. Curtis Nickel and colleagues1) to identify the presence of symptoms indicative of chron...