Objectives: This study aimed to evaluate the effect of crocin and treadmill exercise on oxidative stress, sperm parameters, testis structure in streptozotocin (STZ)-induced diabetic rats. Materials Methods: In this experimental study, 64 rats induced by a single intraperitoneal (IP) injection STZ (50 mg/ kg) were assigned following groups (n=8/each): healthy control group, group treated daily w...

Background: Exercise training and crocin, as a herbal antioxidant, help improve metabolism insulin sensitivity in type 2 diabetes mellitus (T2D). AMP-activated protein kinase (AMPK) nuclear respiratory factor 1 (NRF1) involve the mitochondrial biogenesis pathway control. Objective: This study aimed to investigate effects of high-intensity interval (HIIT), low intensity continued (LICT) combinat...

the present study aimed to evaluate the protective effect of crocin on gastric mucosal lesions caused by ischemia-reperfusion (i/r) injury in rats.forty male rats were randomly divided into sham, control (i/r injury) and three crocin-pretreated groups. to induce i/r lesions, the celiac artery was clamped for 30 min and then the clamp was removed to allow reperfusion for 3 h. pretreated-rats rec...

Crocins in commercial liquid saffron extracts (Saffr’activ®) were identified using high-performance chromatography (HPLC) with a diode array detector (DAD) and mass spectrometry (MS). The impact of storage on the qualities extract studied HPLC-DAD-MS by exposing trans-4-GG crocin to environmental factors. Light temperature induced degradation after only one week. Trans-4-GG was totally hydrolyz...

objective(s):long-term treatment with antipsychotics causes serious side effects such as tardive dyskinesia that characterized by abnormal movements in the orofacial region. oxidative stress in the brain specific area is implicated in the pathophysiology of tardive dyskinesia. in this study the protective effect of crocin on haloperidol-induced orofacial dyskinesia was evaluated. materials and ...

Aim of this study is to confirm and investigate the diuretic effect of crocine which is the pharmacologically active component of Crocus sativus L. (saffron) and to study the possible mechanism of action in relation to urinary nitrite. Twenty four rats were divided into 3 groups; control, hydrochlorothiazide and crocine treated groups. Assay of the diuretic activity of crocine was performed by ...

Aim of this study is to confirm and investigate the diuretic effect of crocine which is the pharmacologically active component of Crocus sativus L. (saffron) and to study the possible mechanism of action in relation to urinary nitrite. Twenty four rats were divided into 3 groups; control, hydrochlorothiazide and crocine treated groups. Assay of the diuretic activity of crocine was performed by ...

Background: Squamous cell carcinoma (SCC) is the most common oral malignancy with high rate of mortality. Cisplatin, as effective chemotherapy drug, has side effects. Considering studies on use crocin in saffron treatment various malignancies, this study aimed at investigating effects and cisplatin their combination SCC fibroblast lines. Materials Methods: In interventional study, HN5 lines wer...

COVID-19 was originated in Wuhan, China, December 2019 and has been declared a pandemic disease by WHO. The number of infected cases continues unabated so far, no specific drug approved for targeted therapy. Hence, there is need discovery from traditional medicine. Tiryaq-e-Wabai well-documented formulation Unani medicine its wide use as prophylaxis during epidemics cholera, plague other earlie...