flavonoids, are a large class of polyphenols, with more than 4000 combinations. they have an antioxidant role in plant photosynthesis and in the human body they optimally act as an antioxidant, anti-inflammatory, anticancer and protector of the heart. quercetin is in the flavonol group that is used to fight protection specifically against viruses and cancer cells. in this study, comparison of e...

The application of the Quality by Design (QbD) concept to extracts obtained from Crocus sativus perianth with potential anticancer activity will ensure safety, efficiency, and quality control entire technological process, as well determine critical factors affecting extracts. Potentially points production plant extracts, including cultivation processing materials, extraction choice solvents, we...

background & aim: saffron (crocus sativus l.) formerly was important in turkey. saffron cultivation has been decreased and it is now only cultivated in three villages in this country. it is triploid and exclusively propagated in a vegetative way by corms. in turkey, saffron is traditionally planted by placing corms in rows randomly without grading or sorting; which results in placement of c...

background: tuberculosis continues to be a common health problem worldwide. rifampin, an antibiotic used routinely for tuberculosis chemotherapy is documented to be a potent hepatotoxicant. the aim of the present study was to assess the antioxidant activity of ethanolic extract of crocus sativus l . stigma (eecsl.s) against rifampin induced hepatotoxicity in the rats. materials and methods: mal...

Aims: Previous investigations have confirmed the anti-inflammatory and analgesic effects of aqueous-ethanol extract of saffron on formalin induced pain in small male mice. Since there is difference between ethanol and aqueous-ethanol extract of saffron, this study was performed in order to evaluate the effect of ethanol saffron extract on acute and chronic pain in small male mice. Materials & M...

Background: Saffron (Crocus sativus L.) is traditionally used as a spice for coloring and flavoring in cooking in some countries. One of the main component of saffron is Crocin. Recent researches have shown Crocin has various pharmacological effects. The aim of this study was to assess the effect of Crocin on the Pituitary-Gonadal Axis and Kiss-1 gene expression in hypothalamus and also ovarian...

Objective(s): Exposure to electromagnetic fields (EMF) emitted from mobile phones may cause a deleterious effect on human health and may affect the male reproductive system. Crocin, a carotenoid isolated from Crocus Sativus L. (Saffron), is a phar‌macologically active component of saffron. So, this study was conducted to investigate the protective effect of crocin on t...

Background: Acetaminophen (APAP) is a common analgesic and antipyretic medicine that can lead to acute liver injury at high doses. Crocin, Crocus sativus’ ingredient, has potent antioxidant effects. Objectives: This study examined the protective effects of crocin against APAP-induced oxidative stress in mice. Methods: In this study, 56 mice were randomly divided into seven groups (n = 8 per gro...

Alzheimer’s disease (AD) is a neurodegenerative disease and the leading cause of dementia worldwide. Epidemiological studies support the important role of diet in prevention and improvement of AD. In Traditional Persian Medicine (TPM), there is multiple dietary guidelines to prevent and alleviate dementia and memory impairment. Pharmacological studies have been shown that most of the TPM-recomm...