BACKGROUND The morbidity and mortality associated with depression are considerable and continue to increase. Depression currently ranks fourth among the major causes of disability worldwide, after lower respiratory infections, prenatal conditions, and HIV/AIDS. Crocus sativus L. is used to treat depression. Many medicinal plants textbooks refer to this indication whereas there is no evidence-ba...

Saffron (Zaaferan), botanical name Crocus sativus, is the most expensive spice in the world. It is derived from the dried stigma and pistil of the purple saffron crocus flowers. Iran is the largest saffron producer accounting for more than 80% of the world's production. Saffron contains an aeroallergen that causes reactive respiratory allergic reactions in atopic subjects. IgG antibody to aller...

objective: asthma is a chronic inflammatory disease of the respiratory airways distinguished by edema and infiltration of inflammatory immune cells. to test our hypothesis about the anti-inflammatory effect of saffron, we examined effects of crocus sativus (c. sativus) extract as a prophylactic anti-inflammatory agent in sensitized rats. materials and methods: to induce experimental asthma, rat...

saffron or crocus sativus l. (c. sativus) has been widely used as a medicinal plant to promote human health, especially in asia. the main components of saffron are crocin, picrocrocin and safranal. the median lethal doses (ld50) of c. sativus are 200 mg/ml and 20.7 g/kg in vitro and in animal studies, respectively. saffron has been suggested to be effective in the treatment of a wide range of d...

background: tuberculosis continues to be a common health problem worldwide. rifampin, an antibiotic used routinely for tuberculosis chemotherapy is documented to be a potent hepatotoxicant. the aim of the present study was to assess the antioxidant activity of ethanolic extract of crocus sativus l . stigma (eecsl.s) against rifampin induced hepatotoxicity in the rats. materials and methods: mal...

background: allergy to saffron (crocus sativus) pollen has been described in people involved in processing of saffron flower stamens. profilins have been identified as a pan-allergen in different plant pollens and foods. this molecule is an actin-binding pro-tein with a molecular weight of 12-16 kda found in eukaryotic species. objective: the aim of this study was to generate monoclonal antibod...