Multinational companies frequently work with manufacturers that receive large orders for different products (or product varieties: size, shape, color, texture, material), to serve thousands of final destinations (e.g., shops) requesting a combination quantities each product. It is not the manufacturers’ task create individual shipments destination. But can deliver part their production in so-ca...

This paper studies the integration of vehicle routing problem with cross-docking (VRPCD). The aim is to find a set routes deliver products from suppliers customers through cross-dock facility, such that operational and transportation costs are minimized, without violating capacity time horizon constraints. A two-phase matheuristic based on column generation proposed. first phase focuses generat...

Due to mismanagement of supply chain operations, fresh produce, which deteriorates highly depending on time and operating environment (including temperature humidity), will suffer huge losses in transit, resulting substantial monetary losses. Cross-docking, as an efficient logistics operation strategy, has been widely used produce distribution the cold chain, whereas it not received adequate at...

Abstract Cross-docking is a supply chain distribution and logistics strategy for which less-than-truckload shipments are consolidated into full-truckload shipments. Goods stored up to maximum of 24 hours in cross-docking terminal. In this chapter, we build on the literature review by Ladier Alpan (2016), who reviewed research conducted interviews with managers find gaps provide recommendations ...

MDM2 is a negative regulator of p53 activity and an important target for cancer therapeutics. The N-terminal lid region of MDM2 modulates interactions with p53 via competition for its binding cleft, exchanging slowly between docked and undocked conformations in the absence of p53. To better understand these dynamics, we constructed Markov State Models (MSMs) from large collections of unbiased s...

Cells are interactive living systems where proteins movements, interactions and regulation are substantially free from centralized management. How protein physico-chemical and geometrical properties determine who interact with whom remains far from fully understood. We show that characterizing how a protein behaves with many potential interactors in a complete cross-docking study leads to a sha...

background: tubulin protein being the fundamental unit of microtubules is actively involved in cell division thus making them a potential anti-cancer drug target. in spite of many reported drugs against tubulin, few of them have started developing resistance in human β-tubulin due to amino acid substitutions. methods: in this study we generated three mutants (f270v, a364t and q292e) using model...

An unusually large data set of 397 piperazinyl-glutamate-pyridines/pyrimidines as potent orally bioavailable P2Y(12) antagonists for inhibition of platelet aggregation was studied for the first time based on the combination of three-dimensional quantitative structure-activity relationship (3D-QSAR), molecular docking, and molecular dynamics (MD) methods. The comparative molecular field analysis...

BACKGROUND Cross-docking is an approach to find the best holo structures among multiple structures available for a target protein. RESULTS CrossDocker significantly decreases the time needed for setting parameters and inputs for performing multiple dockings, data collection and subsequent analysis. CONCLUSION CrossDocker was written in Python language and is available as executable binary f...

Side-chain or even backbone adjustments upon docking of different ligands to the same protein structure, a phenomenon known as induced fit, are frequently observed. Sometimes point mutations within the active site influence the ligand binding of proteins. Furthermore, for homology derived protein structures there are often ambiguities in side-chain placement and uncertainties in loop modeling w...