BACKGROUND We aimed to evaluate empirically how crossover trial results are analysed in meta-analyses of randomized evidence and whether their results agree with parallel arm studies on the same questions. METHODS We used a systematic sample of Cochrane meta-analyses including crossover trials. We evaluated the methods of analysis for crossover results and compared the concordance of the esti...

The Evolutionary Algorithm is a population-based metaheuristic optimization algorithm. The EA employs mutation, crossover and selection operators inspired by biological evolution. It is commonly applied to find exact or approximate solutions to combinatorial search and optimization problems. This dissertation describes a series of theoretical and experimental studies on a variety of evolutionar...