OBJECTIVE C-reactive protein (CRP) has been associated with risk of cardiovascular disease. It is not clear whether CRP is causally involved in the development of atherosclerosis. Mouse CRP is not expressed at high levels under normal conditions and increases in concentration only several-fold during an acute phase response. Because the dynamic range of human CRP is much larger, apolipoprotein ...

OBJECTIVE In addition to being a cardiovascular risk marker, recent studies support a role for CRP in atherothrombosis. Several investigators have reported that CRP binds to Fcgamma receptors on leukocytes. The aim of the study is to determine the processing of CRP by human aortic endothelial cells (HAECs). METHODS AND RESULTS Binding studies were performed by incubation of HAECs with biotiny...

The cAMP receptor protein (CRP, also known as CAP) functions as a transcriptional activator at more than 100 different E. coli operons (3). CRP is arguably one of the most well-understood transcriptional activators. At simple CRP-dependent promoters, where CRP is the only activator, transcription activation by CRP involves direct contact with RNA polymerase at two distinct sites. These contacts...

OBJECTIVE To explore how C-reactive protein (CRP) tests serve to support physicians in decisions concerning antibiotic prescription to patients with respiratory tract infections (RTI). DESIGN Prospective observational study. SETTING Primary health care centres in western Sweden. SUBJECTS Physicians in primary health care. Patients with acute RTI. MAIN OUTCOME MEASURES Physician willingn...

RATIONALE Baseline circulating concentrations of C-reactive protein (CRP) are significantly associated with cardiovascular disease risk in general populations. This modest association has been inappropriately conflated with causality, and it has been claimed that CRP is proatherogenic. Most of the known causative factors for atherosclerosis stimulate increased CRP production, but comprehensive ...

OBJECTIVE To describe novel C-reactive protein (CRP) molecular forms (mf) in human plasma. DESIGN AND METHODS Five novel CRP-mfs, disctinct from the previously described native (nCRP) and modified (mCRP) C-reactive proteins, were separated from human plasma by polyacrylamide gel electrophoresis and immunodetected by western blot in subjects with or without increased BMI, cardiovascular diseas...

Association Between C-reactive Protein and Carotid Intima-media Thickness in the Young Finns Study To the Editor: It is unclear whether C-reactive protein (CRP), a nonspecific marker of acute phase inflammatory response, is causally related to arterial intima-media thickness (IMT), a risk factor for coronary heart disease (CHD). Previous evidence from conventional observational studies is incon...