Using atomic scale time-dependent density functional calculations we confirm that both diffusion-controlled and diffusionless crystallization modes exist in simple 2D systems. We provide theoretical evidence that a faceted to nonfaceted transition is coupled to these crystallization modes, and faceting is governed by the local supersaturation at the fluid-crystalline interface. We also show tha...

In 1986, Kawashima and their coworkers developed the spherical crystallization technique for size enlargement of the drug in the field of pharmacy. Kawashima defined spherical crystallization as “An agglomeration process that transforms crystals directly into compact spherical forms during the crystallization process.” It also enables co-precipitation of drug and encapsulating polymer in the fo...

The protein structural entries grew far slower than the sequence entries. This is partly due to the bottleneck in obtaining diffraction quality protein crystals for structural determination using X-ray crystallography. The first step to achieve protein crystallization is to find out suitable chemical reagents. However, it is not an easy task. Exhausting trial and error tests of numerous combina...

Recent efforts to collect and mine crystallization data from structural genomics (SG) consortia have led to the identification of minimal screens and novel screening strategies that can be used to streamline the crystallization process. Two groups, the Joint Center for Structural Genomics and the University of Toronto, carried out large-scale crystallization trials on different sets of bacteria...

We present a simple approach to locate sites that undergo conformational changes upon crystallization by comparative structural mapping of the same RNA in three different environments. As a proof of principle, we probed the readily crystallized P4-P6DeltaC209 domain from the Tetrahymena thermophila group I intron in a native solution, in a solution mimicking the crystallization drop, and in cry...

Timescales of magma ascent in conduit models are typically assumed to be much longer than crystallization and gas exsolution for basaltic eruptions. However, it is now recognized that basaltic magmas may rise fast enough for disequilibrium processes to play a key role on the ascent dynamics. The quantification of the characteristic times for crystallization and exsolution processes are fundamen...

Here, the establishment of Europe's largest high-throughput crystallization facility with open access to the general user community is reported. The facility covers every step in the crystallization process from the preparation of crystallization cocktails for initial or customized screens to the setup of hanging-drop vapour-diffusion experiments and their automatic imaging. In its first year o...

Advances in automation have facilitated the widespread adoption of high-throughput vapour-diffusion methods for initial crystallization screening. However, for many proteins, screening thousands of crystallization conditions fails to yield crystals of sufficient quality for structural characterization. Here, the rates of crystal identification for thaumatin, catalase and myoglobin using microfl...

The crystallization and melting behaviors of linear polylactic acid (PLA) treated by compressed CO(2) was investigated. The isothermal crystallization test indicated that while PLA exhibited very low crystallization kinetics under atmospheric pressure, CO(2) exposure significantly increased PLA's crystallization rate; a high crystallinity of 16.5% was achieved after CO(2) treatment for only 1 m...

Although the activity interpretation of sucrose crystallization, already sueessfully applied to pure sucrose solutions and synthetic massesuites (11, does not require any mechanical or molecular model, it does imply (11d) an independence of any structural nature or transport behavior in the operating medium, it is therefore necessary to establish this suggested independence to warrant continued...