نتایج جستجو برای: cu/zn superoxide dismutase (sod1)

تعداد نتایج: 35610  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
T Kondo A G Reaume T T Huang E Carlson K Murakami S F Chen E K Hoffman R W Scott C J Epstein P H Chan

Apoptotic neuronal cell death has recently been associated with the development of infarction after cerebral ischemia. In a variety of studies, CuZn-superoxide dismutase (CuZn-SOD) has been shown to protect the brain from ischemic injury. A possible role for CuZn-SOD-related modulation of neuronal viability is suggested by the finding that CuZn-SOD inhibits apoptotic neuronal cell death in resp...

Journal: :Stroke 1999
M Kawase K Murakami M Fujimura Y Morita-Fujimura Y Gasche T Kondo R W Scott P H Chan

BACKGROUND AND PURPOSE We have demonstrated that copper-zinc superoxide dismutase (CuZn-SOD), a cytosolic isoenzyme of SODs, has a protective role in the pathogenesis of superoxide radical-mediated brain injury. Using mice bearing a disruption of the CuZn-SOD gene (Sod1), the present study was designed to clarify the role of superoxide anion in the pathogenesis of selective vulnerability after ...

Journal: :The Biochemical journal 1984
S L Marklund

A further characterization of human extracellular superoxide dismutase is reported. The study was especially aimed at the interaction with substances known to interfere with CuZn superoxide dismutase and other superoxide dismutases. Extracellular superoxide dismutase is efficiently inhibited by cyanide and is about 3 times more sensitive than is human CuZn superoxide dismutase. The sensitivity ...

Journal: :Stroke 2000
P G Matz J C Copin P H Chan

BACKGROUND AND PURPOSE Subarachnoid hemolysate (SAH) has been associated with oxidative brain injury, cell death, and apoptosis. We hypothesized that over-expression of CuZn-superoxide dismutase (CuZn-SOD) would protect against injury after SAH, whereas reduction of its expression would exacerbate injury. METHODS Saline (n=16) or hemolysate (n=50) was injected into transgenic mice overexpress...

2012
Michael P Pender Peter A Csurhes Casey M M Pfluger Scott R Burrows

REFERENCES 1. Andersen PM, Nilsson P, Keränen ML, et al. Phenotypic heterogeneity in MND-patients with CuZn-superoxide dismutase mutations in Scandinavia. Brain 1997;10:1723e37. 2. Ikeda M, Abe K, Aoki M, et al. Variable clinical symptoms in familial amyotrophic lateral sclerosis with a novel point mutation in the Cu/Zn superoxide dismutase gene. Neurology 1995;45:2038e42. 3. Meyer T, Schwan A,...

Journal: :Cancer research 1981
N G Westman S L Marklund

Superoxide dismutases might conceivably protect against both ionizing radiation and free radical-producing antibiotic antitumor drugs. Copper- and zinc-containing superoxide dismutase (CuZn superoxide dismutase) and manganese-containing superoxide dismutase (Mn superoxide dismutase) were specifically assayed in human malignant tumors and for comparison in human tissues. The tumors possessed les...

Journal: :Journal of the American Society of Nephrology : JASN 2009
Hiroki Fujita Hiromi Fujishima Shinsuke Chida Keiko Takahashi Zhonghua Qi Yukiko Kanetsuna Matthew D Breyer Raymond C Harris Yuichiro Yamada Takamune Takahashi

Superoxide excess plays a central role in tissue damage that results from diabetes, but the mechanisms of superoxide overproduction in diabetic nephropathy (DN) are incompletely understood. In the present study, we investigated the enzyme superoxide dismutase (SOD), a major defender against superoxide, in the kidneys during the development of murine DN. We assessed SOD activity and the expressi...

2004
N. Gunnar Westman Stefan L. Marklund

Superoxide dismutases might conceivably protect against both ionizing radiation and free radical-producing antibiotic antitumor drugs. Copperand zinc-containing Superoxide dismutase (CuZn Superoxide dismutase) and manganese-contain ing Superoxide dismutase (Mn Superoxide dismutase) were specifically assayed in human malignant tumors and for com parison in human tissues. The tumors possessed les...

2004
N. Gunnar Westman Stefan L. Marklund

Superoxide dismutases might conceivably protect against both ionizing radiation and free radical-producing antibiotic antitumor drugs. Copperand zinc-containing Superoxide dismutase (CuZn Superoxide dismutase) and manganese-contain ing Superoxide dismutase (Mn Superoxide dismutase) were specifically assayed in human malignant tumors and for com parison in human tissues. The tumors possessed les...

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