The TLR/IL-1R pathway is a critical signaling module that is misregulated in pathologies like inflammation and cancer. Extracts from turmeric (Curcuma longa L.) enriched in curcumin and carbonyls like turmerones have been shown to exert potent anti-inflammatory effects. The present study evaluated the anti-inflammatory activity, cytotoxic effect and the underlying mechanism of a novel chemicall...

In this paper, detailed meiotic analysis was investigated in seven species of Curcuma (Linnaeus, 1753) which can contribute significantly to our understanding about species inter-relationship, speciation and evolution. The species were divided into two groups viz., Group I having 2n = 42 (C. comosa Roxburgh, 1810, C. haritha Mangaly & M.Sabu, 1993, C. mangga Valeton & Zijp, 1917, and C. motana ...

The efficiency of turmeric fractions, such as petroleum ether, chloroform, benzene, methanol and aqueous were evaluated for their inhibitory effect on clinical standard strains pathogenic bacteria fungus. methanolic fraction Curcuma longa rhizome had high potential to inhibit some i.e. S. aureus a greater degree than other fractions longa. In our study the results show that different (petroleum...

Turmeric is a spice derived from the rhizomes of Curcuma longa, which is a member of the ginger family (Zingiberaceae). Rhizomes are horizontal underground stems that send out shoots as well as roots. The bright yellow color of turmeric comes mainly from fat-soluble, polyphenolic pigments known as curcuminoids. Curcumin, the principal curcuminoid found in turmeric, is generally considered its m...

To identify plants with bioactive potential for skin care, methanol extracts of 56 plant parts from 47 medical and edible plants cultivated in Okinawa were tested for their proliferative effects on NB1RGB skin fibroblast cells. Extracts from six plants, Bischofia javanica, Colocasia esculenta, Melaleuca alternifolia, Piper angustifolia, Jasminum sambac, and Curcuma longa, showed higher NB1RGB c...

Curcumin, an active constituent of Curcuma longa, is responsible for the for anticarcinogenic activities which is mediated through multiple mechanisms. Curcumin affects the major transcription factors such as nuclear factor k-light chain-enhancer of activated B cell(NF-kB) and activator protein-1 (AP-1).These factors regulate inflammation and are responsible for cell proliferation, differentiat...

Herbal remedies are increasingly being recognised in recent years as alternative medicine for a number of diseases including cancer. Curcuma longa L., commonly known as turmeric is used as a culinary spice in India and in many Asian countries has been attributed to lower incidences of gastrointestinal cancers. Curcumin, a secondary metabolite isolated from the rhizomes of this plant has been sh...

Shamima Akhtar SHARMIN, Mohammad Jahangir ALAM, Md. Mominul Islam SHEIKH, Rashed ZAMAN, Muhammad KHALEKUZZAMAN, Sanjoy Chandra MONDAL, Mohammad Anwarul HAQUE, Mohammad Firoz ALAM, Iftekhar ALAM* Division of Applied Life Sciences (BK21 Program), College of Agriculture and Life Science, Gyeongsang National University, Jinju, Republic of Korea Department of Bioscience (Integrated Bioscience Sectio...

This study focused on maximizing the extraction yield of total phenolics and flavonoids from Curcuma Zedoaria leaves as a function of time (80-120 min), temperature (60-80 °C) and ethanol concentration (70-90 v/v%). The data were subjected to response surface methodology (RSM) and the results showed that the polynomial equations for all models were significant, did not show lack of fit, and pre...

Curcuma longa is a plant that belongs to the ginger family, Zingiberaceae. It has been used in Siddha medicine for thousands of years in Asia. Parkinson's disease (PD) is a degenerative disorder of the central nervous system that affects the motor system of the brain. Death of dopamine-producing cells in the substantia nigra leads to PD. Exposure to salsolinol, which is an endogenous neurotoxin...