Islet transplantation is one of many therapeutic approaches for the treatment of diabetes. During transplant procedures, the isolated islets are subjected to hypoxic conditions, and undergo the apoptotic process. Curcumin has a cytoprotective effect, and may therefore be useful for the protection of islets under hypoxia. However, curcumin is hydrophobic, and an efficient curcumin carrier is req...

PURPOSE Telomerase is expressed in most cancers, including breast cancer. Curcumin, a polyphenolic compound that obtained from the herb of Curcuma longa, has many anticancer effects. But, its effect is low due to poor water solubility. In order to improve its solubility and drug delivery, we have utilized a β-cyclodextrin-curcumin inclusion complex. METHODS To evaluate cytotoxic effects of cy...

objective: adipocyte and skeletal muscle are important tissues which contribute the development and progression of metabolic disorder. insulin has a major regulatory function on glucose metabolism in these tissues by redistributing glucose transporter (glut4) from intracellular vesicles to the cell surface. today, due to the side effects of chemical medications attendance to herbal medicines is...

objective: curcumin is a major constituent of turmeric and influences many functions of the brain. in the present study, we investigated the effect of curcumin on yawning induced by apomorphine in rats. materials and methods: curcumin administered orallyfor 10 consecutive days. yawning was induced by subcutaneous (s.c.) injection of apomorphine (a dopamine receptor agonist) and the number of ya...

BACKGROUND Curcumin (diferuloylmethane) shows significant activity across a wide spectrum of conditions, but its usefulness is rather limited because of its low bioavailability. Use of nanoparticle formulations to enhance curcumin bioavailability is an emerging area of research. METHODOLOGY/PRINCIPAL FINDINGS In the present study, curcumin-loaded apotransferrin nanoparticles (nano-curcumin) p...

Curcumin, the yellow pigment in turmeric, prevents malignancies in the intestinal tract of rodents. It is under clinical evaluation as a potential colon cancer chemopreventive agent. The systemic bioavailability of curcumin is low, perhaps attributable, at least in part, to metabolism. Indirect evidence suggests that curcumin is metabolized in the intestinal tract. To investigate this notion fu...

background: organophosphorus pesticides has been widely used in agriculture fields to control various crop insects and their extensive use pose human life at threat because of their adverse effects on human health. in this study, we checked the effects of gst polymorphism on ameliorative effect of curcumin and carvacrol against dna damages. methods: comet assay was used to assess the dna damage...

Curcumin and quercetin are natural compounds with a wide spectrum of activities, including antioxidant and anticancer activities. In this study, the combined effect of the two compounds was investigated, with special emphasis on the pharmacokinetics of curcumin by the quercetin-induced changes in the albumin binding of curcumin. We evaluated the effect of quercetin on the binding of curcumin to...

objective: this study was designed to investigate the antinociceptive effect of curcumin in diabetic rats by using the formalin and hot tail immersion tests. methods: wistar rats were divided into the following six groups:  control; curcumin-treated control (50 mg/kg); diabetic; sodium salicylate (ss)-treated diabetic; and two curcumin-treated diabetic groups (10 and 50 mg/kg). curcumin was ad...

Hyperacidity in the stomach is known to promote the progression of gastric cancer. The plant-derived chemotherapeutic curcumin is used to treat gastric cancer. The objective of this study was to investigate whether curcumin regulates gastrin-mediated acid secretion in suppressing gastric cancer. Gastric cancer cells were treated with 25 μm curcumin, followed by Annexin V/propidium iodide double...