In the past decade in Morocco, there has been a reactivation of zoonotic cutaneous leishmaniasis (ZCL) foci with an unusual long outbreak episode. The aims of this review article were to update our knowledge of this disease in Morocco, to compare the situation with that prevailing in the other countries of the Maghreb region and to highlight factors that could be responsible for the current sit...

We have reported the predominance of Lutzo­ myia whitmani in the peridomicile in our field project area of Tres Braços, Bahia3 where 99% of phlebotomines captured were of this species. This is the suspected vector of Leishmania viannia braziliensis (Lvb) and to date three wild caught flies have been found to harbour this parasite of over 18,000 dissected2. We wish to record here the presence of...

This experimental study was conducted to assess of effectiveness of two nanogold concentrations against cutaneous leishmaniasis (CL) caused by Iranian strain of Leishmania major in BALB/c mice model. Cutaneous lesions were experimentally induced by inoculation with Iranian Leishmania major promastigotes (MRHO/IR/75/ER) in 61 BALB/c mice. The infected mice were enrolled to four groups: intervent...

The present study reports the production of the rabbit anti-Leishmania (L.) chagasi hyperimmune serum, the standardization of the immunohistochemistry (IHC) technique and the evaluation of its employment in cutaneous leishmaniasis (CL) lesions diagnosed by Leishmania sp. culture isolation. Thirty fragments of active CL lesions were examined as well as 10 fragments of cutaneous mycosis lesions a...

Autochthonous cases of American cutaneous leishmaniasis (ACL) have been reported since 2001 in the Xakriabá Indigenous Reserve located in the municipality of São João das Missões in northern Minas Gerais state, Brazil. In order to study the presence of Leishmania DNA in phlebotomine sand flies, six entomological collections were carried out from July 2008 through July 2009, using 40 light traps...

DNA sequencing and microsatellite analyses were performed to investigate the relationship of Sri Lankan cutaneous leishmaniasis isolates to known species of Leishmania. This identified L. donovani as the agent of Sri Lankan cutaneous leishmaniasis, and showed these parasites are closely related to those causing visceral leishmaniasis in the Indian subcontinent.

Abstract Cytolytic CD8 +T cells mediate immunopathology in cutaneous leishmaniasis by a mechanism dependent on degranulation and lysis of Leishmania-infected cells, culminating NLRP3 activation IL-1b release. Here, we sought to identify chemokine receptors involved cell migration the lesion that could be employed as treatment target ameliorate disease severity. A transcriptional study identifie...