the world health organization (who) has supported and recommended study and research on the various aspects of leishmaniasis which is one of the six major tropical region diseases. cutaneous leishmaniasis is considered as a common parasitic disease in iran. considering the fact that few studies have been conducted about some centers of disease such as khorram-shahr and the information about the...

An important NK-cell inhibition with reduced TNF-α, IFN-γ and TLR2 expression had previously been identified in patients with diffuse cutaneous leishmaniasis (DCL) infected with Leishmania mexicana. In an attempt to pinpoint alterations in the signaling pathways responsible for the NK-cell dysfunction in patients with DCL, this study aimed at identifying differences in the NK-cell response towa...

References 1. Cook GC, editor. Manson’s tropical diseases. 20th ed. Philadelphia: Saunders; 1996. p. 1213-45. 2. Weir E. Buruli ulcer: the third most common mycobacterial infection. CMAJ 2002;166(13):1691. 3. Weigle KA, de Davalos M, Heredia P, Molineros R, Saravia NG, D’Alessandro A. Diagnosis of cutaneous and mucocutaneous leishmaniasis in Colombia: a comparison of seven methods. Am J Trop Me...

background cutaneous leishmaniasis is the most common form of leishmaniasis caused by flagellate protozoa of the genus leishmania transmitted by sand fly bites. old world leishmaniasis is endemic in the mediterranean sea and the neighbouring countries. we believe, that this case is interesting by the fact that we had a very rear disease case that can be observed in nonendemic area. we present a...

All adults (n = 334) living in Brejo do Mutambal, an endemic area for cutaneous leishmaniasis, were included in this study. Contrary to our initial hypothesis, it was observed that men (23.7 +/- 3.2 vs. 22.1 +/- 2.6 kg/m(2)) and women (24.1 +/- 4.7 vs. 22.5 +/- 3.4 kg/m(2)) with cutaneous leishmaniasis presented higher body mass index than the controls.

BACKGROUND Leishmaniasis covers a range of clinical manifestations. Estimation of the burden of leishmaniasis may help guide healthcare management personnel and policy-makers in applying effective interventions. The present study aimed to calculate the incidence and burden of cutaneous and visceral leishmaniasis in Iran in 2013. METHODS To evaluate the epidemiological aspects of the disease i...

Serum IgE levels and the expression of low affinity receptor for IgE (Fc epsilon RII/CD23) are increased in cutaneous leishmaniasis. The ligation of CD23 receptor by IgE-anti-IgE immune complexes results in nitric oxide (NO) production, which is a critical leishmanicidal factor. Human monocytes/macrophages express Fc epsilon RII/CD23 after activation with IFN-gamma and IL-4. In the present stud...

Cell-mediated immunity requires costimulatory activity to initiate or inhibit antigen-specific T-cell responses. CTLA-4 is an inhibitory receptor expressed by activated and regulatory T cells. The single nucleotide polymorphism (SNP) +49 A/G of the CTLA-4 gene alters intracellular distribution of CTLA-4, interleukin-2 production, and, as a consequence, T-cell proliferation. The aim of this stud...

background cutaneous leishmaniasis with zoonotic and anthroponotic forms is an endemic disease and a health problem in our country. identification of parasite species and the type of disease is very important for treatment of disease as well as planning the control program. this study was carried out to identify the parasite species causing cutaneous leishmaniasis by nested pcr in poledokhtar d...

Approximately 6,000 cases of cutaneous leishmaniasis are reported annually in Colombia, a greater than twofold increase since the 1980s. Such reports certainly underestimate true incidence, and their geographic distribution is likely biased by local health service effectiveness. We investigated how well freely available environmental data explain the distribution of cases among 1,079 municipali...