The etiology of non-Hodgkin's lymphomas (NHL) remains a controversial matter, but, in the last few years, considerable evidence suggests that aberrations of the immune system and viruses may act as etiologic agents, in at least some cases of NHL. In fact, patients with primary immuno-deficiencies, or those suffering from diseases characterized by autoimmune dysfunction, show an increased risk f...

Human T-cell lymphotropic virus type I (HTLV-I) infection is associated with a variety of human diseases including HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), a chronic progressive inflammatory neurological disease. An important risk factor for the development of HAM/TSP is thought to be a high HTLV-I proviral load. Histopathological studies have demonstrated the presen...

conclusions this epidemiological study indicated different rates and transmission risks for these viruses. hcv was the most contagious viral infection and htlv-i was the weakest in the prisoners. apart from kshv infection which its prevalence was as twice as in the general population, the prevalence of hbv and htlv-i in prisoners was nearly in ranges of the general population. background prison...

Human T-cell Lymphotropic Virus Type I (HTLV-I) primarily infects CD4+ helper T cells. HTLV-I infection is clinically linked to the development of Adult T-cell Leukemia/Lymphoma and of HTLV-I Associated Myelopathy/Tropical Spastic Paraparesis, among other illnesses. HTLV-I transmission can be either horizontal through cell-to-cell contact, or vertical through mitotic division of infected CD4+ T...

Karyotypes of 26 human lymphocyte cultures, infected or noninfected with human T-lymphotropic virus type I (HTLV-I), with or without Epstein-Barr virus infection, were analyzed by G-banding. Hypodiploidy and structural abnormalities were seen more frequently in HTLV-I-infected cultures (30%) than in virus noninfected cultures (10%) propagated for less than 200 days. In all of six immortalized c...

Simian T-lymphotropic virus type 1 (STLV-1) strains occasionally infect humans. However, the frequency of such infections is unknown. We show that direct transmission of STLV-1 from nonhuman primates to humans may be responsible for a substantial proportion of human T-lymphotropic virus type 1 infections in rural Côte d'Ivoire, where primate hunting is common.