Background: Oxidative stress associated with vascular damage represents one the major contributor in pathogenesis of systemic sclerosis (SSc) [1]. Indeed, different studies demonstrated that excessive free radicals production can contribute to activation fibrotic process skin and visceral organs CXCL10 CXCL11, together their receptor CXCR3, are involved fibrosis [2]. Furthermore, these chemokin...

IL-1-related cytokines share similarities in their receptor distribution and signalling pathways; however, overlapping actions of these cytokines have not been clearly demonstrated. The aim of our study was to compare the capacity of different IL-1-related cytokines to stimulate production and release of multiple CC and CXC chemokines by epithelial cells. The chemokine gene expression was studi...