نتایج جستجو برای: cxcr4 gene expression
تعداد نتایج: 1607752 فیلتر نتایج به سال:
Purpose: To explore the inhibitory effect and mechanism of action CXCR4 on intervertebral disc degeneration.Methods: The expression was assessed in different degrees degenerate tissues. Nucleus pulposus (NP) cells-induced degeneration were obtained using interleukin 1 beta (IL-1β) stimulation. inhibitor, AMD 3100, employed to resist function CXCR4, order determine whether inhibition acted by ta...
Genome-wide analysis of long noncoding RNA expression profile in nasal mucosa with allergic rhinitis
Abstract Background Long noncoding RNAs (lncRNAs) are involved in a variety of human immune diseases. However, the expression profile and precise function lncRNAs allergic rhinitis (AR) remain unknown. In present study, genome-wide analysis lncRNA was performed nasal mucosa tissue mRNA regulatory relationship examined among patients with or without AR. Methods Microarray assays were differentia...
The development of cervical cancer requires genetic and epigenetic factors which result in the persistence of a malignant phenotype. Cervical cancer exhibits also some unique differences from other solid tumors. Normal cervical stratified epithelia have characteristics of hypoxic tissue with over-expression of HIF-1 (hypoxia-inducible factor-1) tr...
We hypothesized that the CXC chemokine receptor-4 (CXCR4)-stromal-derived factor-1 (SDF-1) axis may be involved in metastasis of CXCR4(+) tumor cells into the bone marrow and lymph nodes, which secrete the alpha-chemokine SDF-1. To explore this hypothesis, we phenotyped by fluorescence-activated cell sorter analysis various human tumor cell lines for expression of CXCR4 and found that it was hi...
conclusions some results of the correlation coefficients are not the same with visualization. the reason may be due to the small number of data. materials and methods in the foundation-application study, we constructed two-way gene networks using nonparametric methods, such as spearman’s rank correlation coefficient and blomqvist’s measure, and compared them with pearson’s correlation coefficie...
Background : Hodgkin lymphoma is a type of immune system malignancies, constituting about 30% of all cases of lymphomas. It is divided into four subgroups based on histopathologic findings. Recent reports indicate that SDF1 chemokine plays a major role in the development, survival and metastasis of many cancers, including breast, prostate and pancreas. So far, its expression and especially re...
Elevated expression of the chemokine receptors CXCR4 and ACKR3 their cognate ligand CXCL12 is detected in a wide range tumors tumor microenvironment (TME). Yet, molecular mechanisms by which CXCL12/CXCR4/ACKR3 axis contributes to pathogenesis are complex not fully understood. To dissect role this cancer, we discuss its ability impinge on canonical less conventional signaling networks different ...
The genetic hallmark of hemangioblastomas and clear cell-renal cell carcinomas (CC-RCCs) is loss-of-function of the von Hippel-Lindau (VHL) tumor suppressor protein. VHL is required for oxygen-dependent degradation of hypoxia-inducible factor-1alpha (HIF-1alpha). In hemangioblastomas and CC-RCCs, HIF-1alpha is constitutively overexpressed leading to increased transcription of HIF-1-regulated ge...
Aberrant chemokine (C-X-C motif) receptor CXCR4 expressions in malignant tissues have been reported, but its role in gastric cancer prognosis remains unknown. Our studies were designed to investigate the expression and prognostic significance of CXCR4 in patients with gastric cancer. CXCR4 expression was retrospectively analyzed by immunohistochemistry in 97 patients with gastric adenocarcinoma...
RNA interference technology, silencing targeted genes in mammalian cells, has become a powerful tool for studying gene function. For the first time in cancer research, we show that direct injection of a pool of naked small interfering RNA (siRNA) duplexes can prevent tumorigenesis in an animal model, suggesting a novel preventive and therapeutic strategy for cancer management. As a model system...
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