The cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) play an important role in the regulation of airway smooth muscle tone and activation of inflammatory cells. Intracellular concentrations of these nucleotides are tightly regulated by phosphodiesterases (PDEs). Several families of PDEs are now recognized and, within each isoenzyme family, mole...

s, p. 79.51. Ellis, D. B. Synthesis and secretion of respiratory tract mucin by tracheal explants. Mod. Probl. Paediat. 19: 110-119 (1976).52. Butcher, F. R., and Putney, J. W, Jr. Regulation of parotid gland function by cyclic nucleotides and calcium. Adv. Cyclic Nucl. Res.13: 215-249 (1980). 53.Schulz, I., and Stolze, H. H. The exocrine pancreas: the role ofsecretagogues, ...

Cyclic adenosine 3':5'-monophosphate-dependent protein kinase (kinase A) and cyclic guanosine 3':5'-monophosphate-dependent protein kinase (kinase G) were assayed in lymphocytes of normal subjects, adults with chronic lymphocytic leukemia (CLL), and children with acute lymphocytic leukemia (ALL). There was a good correlation between the activity of the two kinases and the level of the correspon...